Biography
I am a bioinformatician researching the genetic epidemiology of breast cancer and other cancers. As a member of the BCAC and Cimba consortia I have taken a key role in the genotyping, imputation and analysis of three large breast cancer genome-wide association studies (iCOGS, Oncoarray and Confluence). I support a number of research projects that are trialling the clinical implementation of polygenic risk scores. I have a particular interest in the role of genetic structural variants (deletions, duplications, insertions and tandem repeats) and am completing a Phd on this topic. I developed a method to detect rare deletions and duplications from genotyping array data and tested these for association in a large dataset.
Publications
Dennis, J., Tyrer, J.P., Walker, L.C. et al. Rare germline copy number variants (CNVs) and breast cancer risk. Commun Biol 5, 65 (2022).
Dennis, J., Walker, L., Tyrer, J., Michailidou, K. & Easton, D.F. Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation of z-scores improves detection and reliability. Genet. Epidemiol. 45, 237–248 (2020).
Amber A DeVries, Joe Dennis, Jonathan P Tyrer, et al., Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci, JNCI: Journal of the National Cancer Institute, Volume 114, Issue 11, (2022)
Mavaddat N , Michailidou K , Dennis J , Lush M , Fachal L , Lee A , et al. Polygenic risk scores for prediction of breast cancer and breast cancer subtypes. Am J Hum Genet 2019
Michailidou, K., Lindström, S., Dennis, J. et al. Association analysis identifies 65 new breast cancer risk loci. Nature 551, 92–94 (2017)
Michailidou, K., Hall, P., Gonzalez-Neira, A. et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 45, 353–361 (2013)
