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Read more at: Machine learning for prediction of childhood mental health problems in social care

Machine learning for prediction of childhood mental health problems in social care

6 June 2025

Katherine Parkin and Efthalia Massou, Primary Care Unit, Department of Public Health and Primary Care. What we found... 1. Machine learning performance in the prototypes was promising, though more work will be needed to develop these models into clinically usable tools. 2. Linking data together from different sources helps...

Read more at: Artificial intelligence for diagnostics in radiology practice: a rapid systematic scoping review

Artificial intelligence for diagnostics in radiology practice: a rapid systematic scoping review

6 June 2025

Stephen Morris, Efthalia Massou and Kevin Herbert, Primary Care Unit, Department of Public Health and Primary Care Stephen Morris , Efthalia Massou and Kevin Herbert have co-authored a recent article published in eClinicalMedicine titled "Artificial intelligence for diagnostics in radiology practice: a rapid systematic...

Read more at: What is an identifier good for? Issues in using visual identifiers to improve care for people with dementia in hospital

What is an identifier good for? Issues in using visual identifiers to improve care for people with dementia in hospital

6 June 2025

Katalina Kuberska and Graham Martin, THIS Institute, Department of Public Health and Primary Care Providing good-quality care for people inpatients who suffer with cognitive impairment, for example dementia, can be challenging. Patients with dementia have needs that are not always met by already busy healthcare staff. One...

Read more at: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of breast cancer: a retrospective cohort study using linked electronic health records

Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of breast cancer: a retrospective cohort study using linked electronic health records

6 June 2025

Antonis Antoniou and Hend Hassan, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care Carriers of BRCA1 and BRCA2 pathogenic variants (PV) are at elevated risk of developing breast and ovarian cancer. To mitigate ovarian cancer risk, bilateral salpingo-oophorectomy (BSO) is commonly...

Read more at: Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction

Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction

6 June 2025

Michael Inouye, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care The complete blood count is amongst the most routinely ordered clinical laboratory tests performed globally. The levels of blood cell traits frequently inform clinical decision making and are strongly affected by genetics...

Read more at: Help us identify community nurses’ contributions to end-of-life care with the Notice Study

Help us identify community nurses’ contributions to end-of-life care with the Notice Study

19 May 2025

University of Cambridge researchers are conducting a short survey investigating what proportion of community nurses’ daily work involves providing care for people in their last year of life. Led by Dr Ben Bowers, Wellcome Post-Doctoral Research Fellow, and Primary Care Unit, and Joodi Mourhli, Research Assistant, both...

Read more at: Diagnostic inequalities relating to physical healthcare among people with mental health conditions: a systematic review

Diagnostic inequalities relating to physical healthcare among people with mental health conditions: a systematic review

8 May 2025

Elisa Liberati, THIS Institute, Department of Public Health and Primary Care People with mental health conditions are also at increased risk of physical illnesses: for example, they are up to twice as likely to have cardiometabolic conditions as those without mental health conditions. The reasons for this are complicated...

Read more at: Harnessing multi-omics to define how genetic changes impact biological processes and health outcomes

Harnessing multi-omics to define how genetic changes impact biological processes and health outcomes

8 May 2025

Elodie Persyn, Dirk S Paul and Michael Inouye, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care We are excited to share our collaborative manuscript published in Nature Genetics . As part of an international team from the Wellcome Sanger Institute, University of Cambridge, AstraZeneca, and...

Read more at: Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease

Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease

8 May 2025

Carles Foguet and Michael Inouye, Cardiovascular Epidemiology Unit Department of Public Health and Primary Care A major challenge in understanding the contribution of genetic variation to disease risk is the fact that genetic variants can act within complex biological networks, such as the human metabolic network, which...

Read more at: Proteogenomic signatures of type 2 diabetes and its comorbidities

Proteogenomic signatures of type 2 diabetes and its comorbidities

8 May 2025

Dirk S Paul and Michael Inouye, Cardiovascular Epidemiology Unit Department of Public Health and Primary Care We are delighted to share our work on the proteogenomics of type 2 diabetes and related comorbidities published in Nature Communications . The study used large-scale genomic and proteomic data from the UK Biobank...

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