Biography
Dr Stephen Kaptoge is a senior statistician at the Cardiovascular Epidemiology Unit (CEU), where he has worked since 2005. He is a graduate of the University of Cambridge (PhD Epidemiology 2005, MPhil Statistical science 2000) and University of Nairobi (BSc Mathematics 1998).
Research
Dr Kaptoge has strong interests in applied statistics and epidemiology (principally cardiovascular disease and osteoporosis), which mainly involves meta-analysis of individual participant data (IPD) in large-scale collaborative studies to assess the relevance of biomarkers, lifestyle factors, and genetic risk factors to disease, with potential to improve scientific understanding, risk prediction, and public health. He leads the development and implementation of applied statistical methods for IPD meta-analysis [1, 2, 3] and provides overall statistical support to the CEU research programmes.
Dr Kaptoge has specific epidemiological interests in studying the relevance of inflammation to cardiovascular disease, for which he has performed literature-based meta-analysis [4, 5] and led IPD meta-analyses in the Emerging Risk factors Collaboration (ERFC) [6, 7, 8]. He is currently mainly involved in risk prediction [3, 7] and public health modelling [9]. He is the principal investigator/scientific coordinator of the Vitamin D Studies Collaboration (VitDSC) and is a statistical member of the independent data monitoring committee of the INTERVAL study. He has published key papers in the field of osteoporosis [10, 11, 12], and has led work packages in the EU funded genetic factors for osteoporosis (GEFOS) consortium, involving collaborative meta-analysis of genome-wide determinants of heel bone properties [13] and assessment of gene-environment interactions.
Publications
Full publication list can be accessed by clicking this link.
Fibrinogen Studies Collaboration, Kaptoge S, White IR, Thompson SG, Wood AM, Lewington S, Lowe GD, Danesh J. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. Am J Epidemiol 2007;166(8):867-79. PM:17785713
Thompson S, Kaptoge S, White I, Wood A, Perry P, Danesh J, Emerging Risk Factors Collaboration. Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol 2010;39(5):1345-59. PM:20439481
Pennells L, Kaptoge S, White IR, Thompson SG, Wood AM. Assessing Risk Prediction Models Using Individual Participant Data From Multiple Studies. Am J Epidemiol 2013. PM:24366051
Danesh J, Kaptoge S, Mann AG, Sarwar N, Wood A, Angleman SB, Wensley F, Higgins JP, Lennon L, Eiriksdottir G, Rumley A, Whincup PH, Lowe GD, Gudnason V. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med 2008;5(4):e78. PM:18399716
Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A, Di Angelantonio E, Gudnason V, Rumley A, Lowe GD, Jorgensen T, Danesh J. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J 2014;35(9):578-89. PM:24026779
Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 2010;375(9709):132-40. PM:20031199
Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, Butterworth AS, Amouyel P, Assmann G, Bakker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Bjorkelund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D’Agostino RB, Sr., Dankner R, vey-Smith G, Deeg D, Dekker JM, Engstrom G, Folsom AR, Fowkes FG, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jorgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Stehouwer CD, Strandberg TE, Tipping RW, Tosetto A, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GD, Wareham NJ, Khaw KT, Sattar N, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012;367(14):1310-20. PM:23034020
Kaptoge S, Thompson SG, Danesh J. C-reactive protein, fibrinogen, and cardiovascular risk. N Engl J Med 2013;368(1):85-6. PM:23281988
Emerging Risk Factors Collaboration, Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, Njolstad I, Fletcher A, Nilsson P, Lewington S, Collins R, Gudnason V, Thompson SG, Sattar N, Selvin E, Hu FB, Danesh J. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 2011;364(9):829-41. PM:21366474
Kaptoge S, Beck TJ, Reeve J, Stone KL, Hillier TA, Cauley JA, Cummings SR. Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fractures. J Bone Miner Res 2008;23(12):1892-904. PM:18684092
Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J. Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone 2003;32(5):561-70. PM:12753873
Kaptoge S, Benevolenskaya LI, Bhalla AK, Cannata JB, Boonen S, Falch JA, Felsenberg D, Finn JD, Nuti R, Hoszowski K, Lorenc R, Miazgowski T, Jajic I, Lyritis G, Masaryk P, Naves-Diaz M, Poor G, Reid DM, Scheidt-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Roy DK, Lunt M, Pye SR, O’Neill TW, Silman AJ, Reeve J. Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study. Bone 2005;36(3):387-98. PM:15777673
Moayyeri A, Hsu YH, Karasik D, Estrada K, Xiao SM, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng HF, Smith AV, Pye SR, Leo PJ, Teumer A, Hwang JY, Ohlsson C, McGuigan F, Minster RL, Hayward C, Olmos JM, Lyytikainen LP, Lewis JR, Swart KM, Masi L, Oldmeadow C, Holliday EG, Cheng S, van Schoor NM, Harvey NC, Kruk M, Fabiola Del GM, Igl W, Trummer O, Grigoriou E, Luben R, Liu CT, Zhou Y, Oei L, Medina-Gomez C, Zmuda J, Tranah G, Brown SJ, Williams FM, Soranzo N, Jakobsdottir J, Siggeirsdottir K, Holliday KL, Hannemann A, Go MJ, Garcia M, Polasek O, Laaksonen M, Zhu K, Enneman AW, McEvoy M, Peel R, Sham PC, Jaworski M, Johansson A, Hicks AA, Pludowski P, Scott R, Dhonukshe-Rutten RA, van d, V, Kahonen M, Viikari JS, Sievanen H, Raitakari OT, Gonzalez-Macias J, Hernandez JL, Mellstrom D, Ljunggren O, Cho YS, Volker U, Nauck M, Homuth G, Volzke H, Haring R, Brown MA, McCloskey E, Nicholson GC, Eastell R, Eisman JA, Jones G, Reid IR, Dennison EM, Wark J, Boonen S, Vanderschueren D, Wu FC, Aspelund T, Richards JB, Bauer D, Hofman A, Khaw KT, Dedoussis G, Obermayer-Pietsch B, Gyllensten U, Pramstaller PP, Lorenc RS, Cooper C, Kung AW, Lips P, Alen M, Attia J, Brandi ML, de Groot LC, Lehtimaki T, Riancho JA, Campbell H, Liu Y, Harris TB, Akesson K, Karlsson M, Lee JY, Wallaschofski H, Duncan EL, O’Neill TW, Gudnason V, Spector TD, Rousseau F, Orwoll E, Cummings S, Wareham NJ, Rivadeneira F, Uitterlinden AG, Prince RL, Kiel DP, Reeve J, Kaptoge SK. Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet 2014. PM:24430505
Teaching and Supervisions
Dr Kaptoge is a mentor to graduate students undertaking MPhil and PhD studies in the department.
