Linda has over 20 years’ experience in the field of Dementia, healthy ageing, neuropsychiatric epidemiology and ethics. She is part of the Cambridgeshire brain bank committee www.cuh.nhs.uk/tissue-bank/cambridge-brain-bank and supports the on-going CFAS brain donation programme in all CFAS study centres in the UK. Coordinates the Cognitive Function and Ageing Studies (CFAS) www.cfas.ac.uk, including:
MRC CFAS: 1989 – Present: Interviewed over 18,000 people aged over 65 years, in their own homes in Cambridge, Oxford, Newcastle, Nottingham, Liverpool and Gwynedd. Data has been collected over a period of more than 25 years, in which over 48,000 interviews with participants have been conducted. The study also includes a unique collection of over 590 donated brains.
CFAS II: 2008 – Present: Interviewed over 7,700 people aged 65 and over in Cambridge, Newcastle and Nottingham using the same recruitment strategy and same geographic areas as MRC CFAS. We have conducted baseline and two year follow up interviews with participants
CFAS II Wales: – 2011 – 2016, recruited in two centres in Wales – Gwynedd and Neath/Port Talbot, who recruited over 3300 people over the age of 65 years. Core findings were incidence and prevalence rates of dementia in Wales, bilingualism, importance of social networks, resilience and cognitive reserve.
The CFAS studies have examined prevalence and incidence of cognitive decline and dementia in England and Wales over two decades. It has looked at the natural history of dementia and cognitive decline, potential risk factors for dementia and the associated levels of disability and frailty found in an ageing population. CFAS has published over 250 research papers on topics such as epidemiology policy, frailty, disability, genetics and molecular neuropathology.
- CFAS II, pilot intervention study – The feasibility and practicality of dementia risk reduction in the older population in Cambridgeshire, Newcastle and Nottingham using an online platform to support behavioural lifestyle change.
- CFAS Doctoral Training Centre – support for the PhD students at each CFAS centre in the UK with projects ranging from Mild Cognitive Impairment (MCI), social isolation, research governance and Multiple medication use.
- EU funded: Prevention of Dementia using Mobile phone Applications (PRODEMOS); WP5 – recruitment of a population based sample from low socio-economic areas in Cambridgeshire. WP 7 – support of website and Dissemination package of the study.
Conducts the intensive training of CFAS Interviewers across all sites and provides ongoing support, training and quality control during fieldwork collections. Supports CFAS PhD, Mphil students and collaborators using the CFAS data and research tools.
- Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II). Wu YT, Prina AM, Jones A, Barnes LE, Matthews FE, Brayne C, CFAS M. Journal of Affective Disorders. 2017. 218:359-64.
- Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: A nested prospective longitudinal cohort study. Richardson SJ, Davis DH, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Allan LM. BMC Geriatrics. 2017. (1):98.
- A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Matthews FE, Stephan BC, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C, Collaboration AS, Comas-Herrera A, Wittenberg R, Dening T. Nature Communications. 2016. 7:11398.
- Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study. Wu YT, Prina AM, Jones A, Barnes LE, Matthews FE, Brayne C, CFAS M. Health & Place. 2016. 38:54-60.
- A multimodal approach to dementia prevention: a report from the Cambridge Institute of Public Health. Olanrewaju O, Clare L, Barnes L, Brayne C. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2015. 1(3):151-6.
- Community Environment, cognitive impairment and dementia in later life: results from the cognitive function and ageing study. Wu YT, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C. Age and Ageing. 2015. 44(6):1005-11.
- Changing non-participation in epidemiological studies of older people: evidence from the Cognitive Function and Ageing Study I & II. Gao L, Green E, Barnes LE, Brayne C, Matthews FE, Robinson L, Arthur A. Age and Ageing. 2015. 44(5):867-73.
- Relocation at older age: results from the Cognitive Function and Ageing Study. Wu YT, Prina AM, Barnes LE, Matthews FE, Brayne C. Journal of Public Health. 2015. 37(3):480-7.
- The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Davis DH, Barnes LE, Stephan BC, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C. BMC Geriatrics. 2014. 14(1):87.
- Assessing environmental features related to mental health: a reliability study of visual streetscape images. Wu YT, Nash P, Barnes LE, Minett T, Matthews FE, Jones A, Brayne C. BMC Public Health. 2014. 14(1):1094.
- A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C, Medical Research Council Cognitive Function and Ageing Collaboration. The Lancet. 2013. 382(9902):1405-12.
- Brain donation for research: consent and re-consent post Alder Hey. Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B. Bulletin of Medical Ethics. 2005. (211):17-21.