Professor of Primary Care Research
MA, MSc, MBBS, MD, FFPH, FRCP(Ed), FMedSci
Email: jm677@medschl.cam.ac.uk | Tel: 01223 330325 | Office: Strangeways’ Research Laboratory
Background
Jonathan Mant is Professor of Primary Care Research at the University of Cambridge. He leads the Cardiovascular Research Group. He trained as a public health physician in the Oxford Region, and from 1992-97 was clinical lecturer in public health medicine at the University of Oxford. From 1997-2008, he was based in the Department of Primary Care & General Practice at the University of Birmingham, moving to Cambridge in October 2008. He was the associate director of the Stroke Research Network with responsibility for primary and community care from 2005-2015, and has chaired several NICE guideline development groups, including most recently for Primary hyperparathyroidism. He is a Fellow of the Academy of Medical Sciences, and an NIHR Senior Investigator.
Research interests
Jonathan’s current research focuses on stroke prevention and treatment in primary care settings. He is the chief investigator on one programme grant funded by NIHR on screening for atrial fibrillation to prevent stroke, and co-lead of a second one on promoting self-management of breathlessness in primary care. He is the co-investigator on further programmes on optimising blood pressure control through supporting medication adherence and on harnessing the use of social media to support asthma care. He is also the co-investigator on a trial of treatment withdrawal in older people with controlled hypertension.
Listen to Jonathan discuss ‘How home blood pressure testing could reduce strokes’ on a Naked Scientists podcast, recorded in 2018.
Watch Jonathan discuss the Screening for Atrial Fibrillation programme on BBC Look East, recorded March 2019.
Selected publications
K Williams, RN Modi, A Dymond, S Hoare, A Powell, J Burt, D Edwards, J Lund, R Johnson, T Lobban, M Lown, MJ Sweeting, H Thom, S Kaptoge, F Fusco, S Morris, G Lip, N Armstrong, MR Cowie, DA Fitzmaurice, B Freedman, SJ Griffin, S Sutton, FDR Hobbs, RJ McManus, J Mant. Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial. BMJ Open. 2022; 12: e065066. https://bmjopen.bmj.com/content/12/9/e065066
A Powell, S Hoare, R Modi, K Williams, A Dymond, C Chapman, S Griffin, J Mant, J Burt. How to embed qualitative research in trials: insights from the feasibility study of the SAFER trial programme. 2022; Trials. 23(1), 1-11. https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06308-7
VL Johnson, L Apps, E Kreit, R Mullis, J Mant, MJ Davies, et al. The feasibility of a self-management programme (My Life After Stroke; MLAS) for stroke survivors. Disability and Rehabilitation. 2022; 1-9. DOI: 10.1080/09638288.2022.2029960
J Mant, RJ McManus. Polypills with or without aspirin for primary prevention of cardiovascular disease. Lancet. 2021; 398: 1106-7. DOI: 10.1016/S0140-6736(21)01913-9
Y Zhu, D Edwards, J Mant, RA Payne, S Kiddle. Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study. BMC Medicine. 2020; 18: 1-11. DOI: 10.1186/s12916-020-01543-8
JP Sheppard, J Burt, M Lown, E Temple, R Lowe, R Fraser, J Allen, GA Ford, C Heneghan, FDR Hobbs, S Jowett, S Kodabuckus, P Little, J Mant, J Mollison, RA Payne, M Williams, L-M Yu, RJ McManus, OPTIMISE Investigators. Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: the OPTIMISE Randomized Clinical Trial. JAMA. 2020; 323(20): 2039-2051. doi:10.1001/jama.2020.4871
C Balasooriya-Smeekens, A Bateman, J Mant, A De Simoni. How primary care can help survivors of transient ischaemic attack and stroke return to work: focus groups with stakeholders from a UK community. British Journal of General Practice. 2020; 70(693), e294-e302. DOI: 10.3399/bjgp20X708149
Z Yang, H Wang, D Edwards, C Ding, L Yan, C Brayne, J Mant. Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis. Ageing Research Reviews. 2020; 57, 100962. DOI: 10.1016/j.arr.2019.100962
GM Turner, R Mullis, L Lim, L Kreit, J Mant. Using a checklist to facilitate management of long-term care needs after stroke: insights from focus groups and a feasibility study. BMC family practice. 2019; 20(1), 2. https://bmcprimcare.biomedcentral.com/articles/10.1186/s12875-018-0894-3
N Heron, F Kee, J Mant, ME Cupples, M Donnelly. Rehabilitation of patients after transient ischaemic attack or minor stroke: pilot feasibility randomised trial of a home-based prevention programme. British Journal of General Practice. 2019; 69(687), e706-e714. DOI: 10.3399/bjgp19X705509
R Mullis, MRJR Aquino, SN Dawson, V Johnson, S Jowett, E Kreit, J Mant. Improving Primary Care After Stroke (IPCAS) trial: protocol of a randomised controlled trial to evaluate a novel model of care for stroke survivors living in the community. BMJ open. 2019; 9(8), e030285. DOI: 10.1136/bmjopen-2019-030285
K Thomas, C Gamlin, A De Simoni, R Mullis, J Mant. How is poststroke fatigue understood by stroke survivors and carers? A thematic analysis of an online discussion forum. BMJ open. 2019; 9 (7), e028958. https://bmjopen.bmj.com/content/9/7/e028958
JP Sheppard, S Stevens, R Stevens, U Martin, J Mant, FDR Hobbs, RJ McManus. Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients with Mild Hypertension. JAMA Intern Med. 2018 Dec 1; 178(12): 1626-1634. DOI: 10.1001/jamainternmed.2018.4684
JP Sheppard, R Stevens, U Martin, J Mant, R Hobbs, R McManus. Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: an observational cohort study. BMJ. 2018 Jun 27; 361: k2478. DOI: 10.1136/bmj.l1541
MA Rashid, N Llanwarne, N Heyns, F Walter, J Mant. What are the implications for practice that arise from studies of medication taking? A systematic review of qualitative research. PLoS One. 2018 May 16; 13(5): e0195076. DOI: 10.1371/journal.pone.0195076
RJ McManus, J Mant, M Franssen, A Nickless, C Schwartz, J Hodgkinson, P Bradburn, A Farmer, S Grant, SM Greenfield, C Heneghan, S Jowett, U Martin, S Milner, M Monahan, S Mort, E Ogburn, R Perera-Salazar, SA Shah, LM Yu, L Tarassenko, FDR Hobbs; TASMINH4 investigators. Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial. Lancet. 2018 Feb 27. pii: S0140-6736(18)30309-X. DOI: 10.1016/S0140-6736(18)30309-X
DM Pindus, R Mullis, L Lim, I Wellwood, AV Rundell, NA Abd Aziz, J Mant. Stroke survivors’ and informal caregivers’ experiences of primary care and community healthcare services – A systematic review and meta-ethnography. PLoS One. 13(2): e0192533 2018. DOI: 10.1371/journal.pone.0192533
RJ McManus, J Mant. Hypertension: New US blood-pressure guidelines – who asked the patients? Nat Rev Cardiol. 2018 Mar; 15(3): 137-138. https://www.nature.com/articles/nrcardio.2017.222
C MacLure, A Martin, CL Saunders, C Meads, FM Walter, SJ Griffin, J Mant, JA Usher-Smith. Reasons why people do not attend NHS Health Checks: a systematic review and qualitative synthesis. Br J Gen Pract. 2018 Jan; 68(666): e28-e35. DOI: 10.3399/bjgp17X693929
M Malhotra, HA Nguyen, O Benavente, M Mete, BV Howard, J Mant, et al. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5. A Systematic Review and Meta-analysis. JAMA Intern Med. 2017; 177(10): 1498-1505. doi:10.1001/jamainternmed.2017.4377.
J Mant, RJ McManus, A Roalfe, K Fletcher, CJ Taylor, U Martin, S Virdee, S Greenfield, FD Hobbs. Different systolic blood pressure targets for people with history of stroke or transient ischaemic attack: PAST-BP (Prevention After Stroke-Blood Pressure) randomised controlled trial. BMJ. 352: i708 2016. doi: https://doi.org/10.1136/bmj.i708
X Xie, E Atkins, J Lv, A Bennett, B Neal, T Ninomiya, M Woodward, S MacMahon, F Turnbull, GS Hillis, J Chalmers, J Mant, A Salam, K Rahimi, V Perkovic, A Rodgers. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2015 Nov 7. pii: S0140-6736(15)00805-3. DOI:https://doi.org/10.1016/S0140-6736(15)00805-3