Professor of Primary Care Research
MA, MSc, MBBS, MD, FFPH, FRCP(Ed), FMedSci
Email: jm677@medschl.cam.ac.uk | Tel: 01223 330325 | Office: Strangeways’ Research Laboratory
Background
Jonathan Mant is Professor of Primary Care Research and Head of the Primary Care Unit at the University of Cambridge. He leads the Cardiovascular Research Group. He trained as a public health physician in the Oxford Region, and from 1992-97 was clinical lecturer in public health medicine at the University of Oxford. From 1997-2008 he was based in the Department of Primary Care & General Practice at the University of Birmingham, moving to Cambridge in October 2008. He was associate director of the Stroke Research Network with responsibility for primary and community care from 2005-2015, and has chaired several NICE guideline development groups, including most recently for Primary hyperparathyroidism. He is a Fellow of the Academy of Medical Sciences, an NIHR Senior Investigator, and chairs NIHR sub-panels for Programme Grants for Applied Research.
Research interests
Jonathan’s current research focuses on stroke prevention and treatment in primary care settings. He is chief investigator on two programme grants funded by NIHR on developing primary care stroke services, and screening for atrial fibrillation to prevent stroke. He is a co-investigator on further programmes on optimising blood pressure control through self monitoring and management and through supporting medication adherence.
Listen to Jonathan discuss ‘How home blood pressure testing could reduce strokes’ on a Naked Scientists podcast, recorded in 2018.
Watch Jonathan discuss the Screening for Atrial Fibrillation programme on BBC Look East, recorded March 2019.
Selected publications
Y Zhu, D Edwards, J Mant, RA Payne, S Kiddle. Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study. BMC Medicine 2020;18:1-11 https://bmcmedicine-biomedcentral-com.ezp.lib.cam.ac.uk/articles/10.1186/s12916-020-01543-8
JP Sheppard, J Burt, M Lown, E Temple, R Lowe, R Fraser, J Allen, GA Ford, C Heneghan, FDR Hobbs, S Jowett, S Kodabuckus, P Little, J Mant, J Mollison, RA Payne, M Williams, L-M Yu, RJ McManus for the OPTIMISE Investigators. Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: the OPTIMISE Randomized Clinical Trial. JAMA. 2020;323(20):2039-2051. doi:10.1001/jama.2020.4871
C Balasooriya-Smeekens, A Bateman, J Mant, A De Simoni. How primary care can help survivors of transient ischaemic attack and stroke return to work: focus groups with stakeholders from a UK community. British Journal of General Practice 2020; 70 (693), e294-e302
Z Yang, H Wang, D Edwards, C Ding, L Yan, C Brayne, J Mant. Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis. Ageing Research Reviews 2020; 57, 100962
GM Turner, R Mullis, L Lim, L Kreit, J Mant. Using a checklist to facilitate management of long-term care needs after stroke: insights from focus groups and a feasibility study. BMC family practice 2019; 20 (1), 2
N Heron, F Kee, J Mant, ME Cupples, M Donnelly. Rehabilitation of patients after transient ischaemic attack or minor stroke: pilot feasibility randomised trial of a home-based prevention programme. British Journal of General Practice 2019; 69 (687), e706-e714
R Mullis, MRJR Aquino, SN Dawson, V Johnson, S Jowett, E Kreit, J Mant. Improving Primary Care After Stroke (IPCAS) trial: protocol of a randomised controlled trial to evaluate a novel model of care for stroke survivors living in the community. BMJ open 2019; 9 (8), e030285
K Thomas, C Gamlin, A De Simoni, R Mullis, J Mant. How is poststroke fatigue understood by stroke survivors and carers? A thematic analysis of an online discussion forum. BMJ open 2019; 9 (7), e028958
Sheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs FDR, McManus RJ. Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension. JAMA Intern Med. 2018 Dec 1;178(12):1626-1634.
Sheppard JP, Stevens R, Martin U, Mant J, Hobbs R, McManus R. Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: an observational cohort study. BMJ. 2018 Jun 27;361:k2478.
Rashid MA, Llanwarne N, Heyns N, Walter F, Mant J. What are the implications for practice that arise from studies of medication taking? A systematic review of qualitative research. PLoS One. 2018 May 16;13(5):e0195076.
McManus RJ, Mant J, Franssen M, Nickless A, Schwartz C, Hodgkinson J, Bradburn P, Farmer A, Grant S, Greenfield SM, Heneghan C, Jowett S, Martin U, Milner S, Monahan M, Mort S, Ogburn E, Perera-Salazar R, Shah SA, Yu LM, Tarassenko L, Hobbs FDR; TASMINH4 investigators. Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial. Lancet. 2018 Feb 27. pii: S0140-6736(18)30309-X
Pindus DM, Mullis R, Lim L, Wellwood I, Rundell AV, Abd Aziz NA, Mant J. Stroke survivors’ and informal caregivers’ experiences of primary care and community healthcare services – A systematic review and meta-ethnography. PLoS One 13(2):e0192533 2018.
McManus RJ, Mant J. Hypertension: New US blood-pressure guidelines – who asked the patients? Nat Rev Cardiol. 2018 Mar;15(3):137-138.
MacLure C, Martin A, Saunders CL, Meads C, Walter FM, Griffin SJ, Mant J, Usher-Smith JA. Reasons why people do not attend NHS Health Checks: a systematic review and qualitative synthesis. Br J Gen Pract. 2018 Jan;68(666):e28-e35
Malhotra, M; Nguyen, HA; Benavente, O; Mete, M; Howard, BV; Mant, J; et al. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5. A Systematic Review and Meta-analysis. JAMA Intern Med. 2017;177(10):1498-1505. doi:10.1001/jamainternmed.2017.4377 Published online September 5, 2017.
Tucker KL, Sheppard JP, Stevens R, Bosworth HB, Bove A, Bray EP, Earle K, George J, Godwin M, Green BB, Hebert P, Hobbs FDR, Kantola I, Kerry SM, Leiva A, Magid DJ, Mant J, Margolis KL, McKinstry B, McLaughlin MA, Omboni S, Ogedegbe O, Parati G, Qamar N, Tabaei BP, Varis J, Verberk WJ, Wakefield BJ, McManus RJ (2017) Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis. PLoS Med 14(9): e1002389.
Mant J, McManus RJ, Roalfe A, Fletcher K, Taylor CJ, Martin U, Virdee S, Greenfield S, Hobbs FD. Different systolic blood pressure targets for people with history of stroke or transient ischaemic attack: PAST-BP (Prevention After Stroke-Blood Pressure) randomised controlled trial. BMJ 352:i708 2016
Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, Chalmers J, Mant J, Salam A, Rahimi K, Perkovic V, Rodgers A. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2015 Nov 7. pii: S0140-6736(15)00805-3.
Yerrakalva D, Mullis R, Mant J. The associations of “fatness,” “fitness,” and physical activity with all-cause mortality in older adults: A systematic review. Obesity (Silver Spring) 23(10):1944-1956 Oct 2015.
Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, et al. An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial. BMJ 350:h468 2015.
Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J, NICE Guideline Development Group for Acute Heart Failure. The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910 2015.