Academic Clinical Fellow

DPhil MB BChir Dipl-Ing (FH)  

Email: cr426@medschl.cam.ac.uk

 

Background

Originally, Christiane completed an undergraduate degree in Chemistry and then went on to do a DPhil and post-doctoral junior research fellowship at Oxford University. At the time, she focused on structural biology and drug design, as well as biophysical methods. Working as a scientist, she was keen to learn more about the biological and medical aspects of cancer research, as well as to work with patients.

She was therefore excited to move on to the Graduate Medical Course in Cambridge, which she completed in 2015 at Hughes Hall. Since then, she has completed the Academic Foundation Programme in the East of England Deanery, working in Bury St. Edmund’s, Huntingdon and Cambridge.

Research Interests

Christiane has joined the Primary Care Institute’s prevention group, working with Dr Juliet Usher-Smith on factors promoting health behaviour change, in particular education about lifestyle changes to reduce cancer risk.  This opens up a new chapter in Christiane’s research portfolio, learning about psychosocial factors affecting health behaviour, as well as intensifying experience in statistical methodologies.

Teaching

Christiane looks forward to contributing to teaching medical students within the department.

Selected Publications

The Structure of an MDM2-Nutlin-3a Complex Solved by the Use of a Validated MDM2 Surface-entropy Reduction Mutant
B. Anil, C. Riedinger, J.A. Endicott and M.E. Noble
Acta Crystallogr D Biol Crystallogr, 2013 Aug; 69(Pt 8):1358-66

Structural and Functional Characterisation of Rpn12 Identifies Residues Required for Rpn10 Proteasome Incorporation
C. Riedinger*, J. Boehringer*, K. Paraskevopoulos, E.O.D. Johnson, C. Khoudian, D. Smith, M.E.M. Noble, C. Gordon & J.A. Endicott
Biochem Journal, 2012. DOI: 10.1042/BJ20120542

MDM2-p53 Protein-protein Interaction Inhibitors: A-ring Substituted Isoindolinones
A. Watson, J. Liu, K. Bennaceur, C. Drummond, J. A. Endicott, B. T. Golding, R. J. Griffin, K. Haggerty, X. Lu, J. M. McDonnell, D. R. Newell, M. E. Noble, C. H. Revill , C. Riedinger, Q. Xu, Y. Zhao, J. Lunec, and I. R. Hardcastle
Bioorg. & Med. Chem. Letters, 2011 Oct1; 21(19):5916-9

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency
R. Hardcastle, J. Lui, A. Watson, S.U. Ahmed, T.J. Blackburn, K. Bennaceur, W. Clegg, C. Drummond, J.A. Endicott, B.T. Golding, R.J. Griffin, J. Gruber, K. Haggerty, R.W. Harrington, C. Hutton, S. Kemp, J.M. McDonnell, D.R. Newell, M.E. Noble, S.L. Payne, C.H. Revill, C. Riedinger, Q. Xu, J. Lunec
J. Med. Chem., 2011, 54 (5)

Understanding Small-Molecule Binding to MDM2: Insights to Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy
C. Riedinger, M.E. Noble, D.J. Wright, F. Mulks, I.R. Hardcastle, J.A. Endicott and J.M. McDonnell
Chem. Biol. Drug Design, 2011 May; 77(5):301-8. DOI: 10.1111/j.1747-0285.2011.01091.x

Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
C. Riedinger, J. Böhringer, J.-F. Trempe, E. Lowe, N.R. Brown, K. Gehring, M. E. M. Noble, C. Gordon and J. A. Endicott
J. Biol. Chem., 2010, 285 (44)

Inhibitors of MDM2 and MDMX: a Structural Perspective
C. Riedinger and J.M. McDonnell
Future Medicinal Chemistry, 2009, 1 (6)

All Change: Protein Conformation and the Ubiquitination Reaction Cascade
C. Riedinger and J.A. Endicott
F1000 Biology Reports, 2009, 19 (1)

Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction
C. Riedinger, J.A. Endicott, S.J. Kemp, L.A. Smyth, A. Watson, E. Valeur, B.T. Golding, R.J.Griffin, I.R. Hardcastle, M.E. Noble and J.M. McDonnell
J. Am. Chem. Soc., 2008, 130 (47)