Prior to joining the Cardiovascular Epidemiology Unit (CEU) in the University of Cambridge, Lingyan completed her PhD at King’s College London, where she worked on the largest Lupus Genome Wide Association Study (GWAS) supervised by Professor Timothy Vyse and Dr. David Morris, to identify disease causal genes and to quantify genetic risk loadings to infer the susceptibility and severity of disease.
Lingyan joined the CEU in 2018 as a statistical geneticist, with a primary interest in investigating potential causal relationships between conventional and novel risk factors and stroke using Mendelian randomization (MR). Currently, she used GWAS results of human plasma proteome and stroke to investigate proteins that are likely to have causal roles in stroke, which may highlight potential novel future therapeutic targets.
Chen, L., Morris, D. L. & Vyse, T. J., Genetic advances in systemic lupus erythematosus: an update. Sep 2017, In : Current Opinion in Rheumatology. 29, 5, p. 423-433
Odhams, C. A., Roberts, A. L., Vester, S. K., Salgado Teixeira Duarte, C., Beales, C. T., Clarke, A. J., Lindinger, S., Daffern, S., Zito, A., Chen, L., Boteva, L., Morris, D. L., Small, K. S., Fernando, M. M. A., Cunninghame Graham, D. S. & Vyse, T. J., Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. April 2019, In: Nature communications 10.1 (2019): 2164.
Odhams, C. A., Cortini, A., Chen, L., Roberts, A. L., Viñuela, A., Buil, A., Small, K. S., Dermitzakis, E. T., Morris, D. L., Vyse, T. J. & Cunninghame Graham, D. S. Mapping eQTLs with RNA-Seq Reveals Novel Susceptibility Genes, Non-Coding RNAs, and Alternative-Splicing Events in Systemic Lupus Erythematosus. 1 Mar 2017, In : Human Molecular Genetics. 26, 5, p. 1003-1017
Morris, D. L., Sheng, Y., Zhang, Y., Wang, Y. F., Zhu, Z., Tombleson, P., Chen, L., Cunninghame Graham, D. S., Bentham, J., Roberts, A. L., Chen, R., Zuo, X., Wang, T., Wen, L., Yang, C., Liu, L., Yang, L., Li, F., Huang, Y., Yin, X. & 12 others. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 2016, In : Nature Genetics. p. 940–946
Bentham, J., Morris, D. L., Cunninghame Graham, D. S., Pinder, C. L., Tombleson, P., Behrens, T. W., Martín, J., Fairfax, B. P., Knight, J. C., Chen, L., Replogle, J., Syvänen, A. C., Rönnblom, L., Graham, R. R., Wither, J. E., Rioux, J. D., Alarcón-Riquelme, M. E. & Vyse, T. J. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 1 Dec 2015, In : Nature Genetics. 47, 12, p. 1457-1464