Student

Email: ljs80@medschl.cam.ac.uk

Telephone: 01223 747228

 Background

Lisa studied Biology at the University of Freiburg (Germany), focusing on Synthetic Biology and Genetics for her MSc. In 2013 she participated in the iGEM synthetic biology competition, where her team engineered novel CRISPR/Cas9 effector systems to modulate gene expression in mammalian cells. Her interest in high-dimensional data was sparked during an internship at the Genetics&Genomics section at F. Hoffmann-La Roche (Basle, Switzerland) in 2015 where she used genotyping & next generation sequencing technologies to inform early-stage drug development projects. She joined the Integrative Human Genomics team as a PhD student in 2016.

Research Interests

Lisa is interested in identifying molecular mechanisms that underlie associations of genetic variants with complex human traits. Being part of the NIHR Blood and Transplant Research Unit in Donor Health and Genomics she is focusing on variants associated with blood cell traits and iron metabolism. In collaboration with the Wellcome Trust Sanger Institute she will use engineered cellular models to decipher the effects of complex haplotype variants on iron homeostasis.

Publications

Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation. Agne M, Blank I, Emhardt AJ, Gäbelein CG, Gawlas F, Gillich N, Gonschorek P, Juretschke TJ, Krämer SD, Louis N, Müller A, Rudorf A, Schäfer LM, Scheidmann MC, Schmunk LJ, Schwenk PM, Stammnitz MR, Warmer PM*, Weber W, Fischer A, Kaufmann B, Wagner HJ, Radziwill G. (2014) ACS Synth Biol. 19;3(12):986-9.
*Joint-first authorship between 18 fellow students  http://www.ncbi.nlm.nih.gov/pubmed/25524106