Before joining the CEU in January 2019, I completed my PhD in Molecular Genetics at the University of Toronto (Canada) under the supervision of Dr. Timothy Hughes. My PhD research focused on the biology of transcription factors (TFs) – developing computational methods to measure and understand the diversity of sequences TFs recognize within and between species, and how this relates to the evolution of gene regulation.
I am currently working on various topics related to Polygenic [Risk] Scores (PGS), a method used to predict an individual’s genetic predisposition for traits and diseases with Dr. Michael Inouye as part of the Cambridge-Baker Systems Genomics Initiative. Currently, I am constructing a new resource, the PGS Catalog, to increase the transparency and reproducibility of PGS by distributing the information necessary for both research and translational uses of PGS for a wide range of diseases and traits. This work is in collaboration with partners at the NHGRI-EBI GWAS Catalog and Health Data Research UK (HDR-UK).
Lambert SA, Yang AWH, Sasse A, Cowley G, Caddick MX, Morris QD, Weirauch MT, Hughes TR. (2019) Similarity regression predicts evolution of transcription factor sequence specificity. Nature Genetics. doi:10.1038/s41588-019-0411-1
Lambert SA*, Jolma A*, Campitelli LF*, Das PK, Yin Y, Albu M, Chen X, Taipale J, Hughes TR, Weirauch MT. (2018). The human transcription factors. Cell. doi:10.1016/j.cell.2018.01.029
Narasimhan K*, Lambert SA*, Yang AWH, Riddell J, Mnaimneh S, Zheng H, Albu M, Najafabadi HS, Reece-Hoyes JS, Fuxman-Bass JI, Walhout AJM, Weirauch MT, Hughes TR. Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities. eLife. doi:10.7554/eLife.06967.001