Telephone: +44 (0)1223 748616
Eleni has worked in Epidemiology of chronic diseases, and in particular has examined health outcomes related to cardiovascular, respiratory and cardiopulmonary diseases. She has assessed environmental exposures, mainly air pollution, and is interested in broadening the identification and evaluation of emerging environmental risk factors including their interplay with genetic susceptibility.
Her current work explores a variety of health outcomes in relation to environmental exposures with a focus on air pollution, nutrients (i.e. Vitamins, Fatty acids), and the interaction of the environment with genetic factors. Ongoing projects include analyses for observational, Mendelian Randomisation (MR) and Genome-wide association (GWAS) studies.
Eleni has worked on identifying environmental risk factors in Pulmonary Arterial Hypertension (PAH), in collaboration with Professor Nick Morell’s research group, University of Cambridge. PAH is a rare cardiopulmonary disease with greatly reduced life expectancy, characterized by high blood pressure confined to the lungs.
Previously, she has worked at University of Athens, towards a National Health Survey, part of the European Health Examination Surveys (EHES). She was based at Durham University as Research Associate, addressing applied health research questions (i.e. evaluation of a programme to prevent colorectal cancer, development of National GP Profiles tool). Finally, she has worked as Research Associate at Newcastle University, providing public health responses on industrial license applications, which was a process embedded on IPPC European Directive, aiming to prevent industrial pollution into air, water and soil.
As part of her PhD fellowship at Newcastle University, she quantified the association between respiratory (asthma, COPD) medication, air quality and deprivation, at primary care level. She employed advanced regression to model seasonal trends (dynamic harmonic regression) and spatial data analysis (i.e. kernel, spatio-temporal autocorrelation tests).
Responsible for the module “Ecological / Geographical Studies”, MPhil in Epidemiology and Public Health.
Eleni has contributed in various modules, part of the MPhil in Epidemiology and Public Health and MPhil in Translational Medicine and Therapeutics.
- Sofianopoulou, E.#, S. Kaptoge, S. Graf, C. Hadinnapola, C. Treacy, C. Church, . . . W.N. Morrell #, Traffic Exposures, Air Pollution And Outcomes In Pulmonary Arterial Hypertension: A United Kingdom Cohort Study Analysis. European Respiratory Journal, 2019. in press. (# denotes joint supervision)
- Touloumi, G., A. Karakatsani, A. Karakosta, E. Sofianopoulou, P. Koustenis, M. Gavana, . . . G. Stergiou, National Survey of Morbidity and Risk Factors (EMENO): Protocol for a Health Examination Survey Representative of the Adult Greek Population. JMIR Res Protoc, 2019. 8(2): p. e10997. |DOI|
- Jiang, X., P.F. O’Reilly, H. Aschard, Y.H. Hsu, J.B. Richards, J. Dupuis, . . . D.P. Kiel, Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun, 2018. 9(1): p. 260. |DOI|
- Sofianopoulou, E., T. Pless-Mulloli, S. Rushton, and P.J. Diggle, Modeling Seasonal and Spatiotemporal Variation: The Example of Respiratory Prescribing. American Journal of Epidemiology, 2017. 186(1): p. 101-108. |DOI|
- Global BMI Mortality Collaboration, Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet, 2016. 388(10046): p. 776-86. |DOI|
- Bevan, R., G. Rubin, E. Sofianopoulou, J. Patnick, and C.J. Rees, Implementing a national flexible sigmoidoscopy screening program: results of the English early pilot. Endoscopy, 2015. 47(3): p. 225-31. |DOI|
- Sofianopoulou, E., S.P. Rushton, P.J. Diggle, and T. Pless-Mulloli, Association between respiratory prescribing, air pollution and deprivation, in primary health care. Journal of Public Health (Oxf), 2013. 35(4): p. 502-9. |DOI|
- Sofianopoulou, E., S. Rushton, G. Rubin, and T. Pless-Mulloli, Defining GP practice areas based on true service utilisation. Health & Place, 2012. 18(6): p. 1248-54. |DOI|