Professor of Cancer Risk Prediction
Academic Course Director MPhil Epidemiology
Telephone: +44 01223 748630
Email: aca20@medschl.cam.ac.uk
Background
Professor Antoniou studied at the London School of Economics and Political Science and the University of Cambridge before gaining his PhD in Genetic Epidemiology at Cambridge in 2001. In 2013 he was appointed a Reader in Cancer Risk Prediction and was promoted to Professor of Cancer Risk Prediction in 2017. He currently leads a research group within the Department of Public Health and Primary Care and he is the Academic Course Director for the MPhil in Epidemiology.
Research
Professor Antoniou’s main research is the development and application of statistical modelling techniques for addressing clinical questions, and the development of risk prediction tools which are used in clinical practice.
Professor Antoniou heads up a research group of 10 which focuses on two broad areas:
- The development and evaluation of risk prediction models for familial breast, ovarian, prostate and other common cancers.
- The implementation of BOADICEA into the CanRisk (canrisk.org) user friendly tool for use by healthcare professionals.
- The characterisation of cancer risks for genetically susceptible individuals, such as those carrying mutations in the the BRCA1, BRCA2, PALB2, RAD51C and RAD51D genes.
Specific ongoing projects include:
CanRisk Programme, which aims to develop and validate quantitative tools for cancer risk stratification and prevention that take advantage of discoveries in both cancer genomics and epidemiology; the development of the BOADICEA risk prediction algorithm which can be used for predicting the risk of developing breast or ovarian cancer and the likelihood of carrying mutations in high risk genes; investigation of genetic modifiers of breast, ovarian and prostate risk for BRCA1 and BRCA2 mutation carriers using data from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
Group Members
| Surname | Forename | Title | Sort Name |
|---|---|---|---|
| Antoniou | Antonis | Professor of Cancer Risk Prediction | Antoniou |
| Leslie | Malgorzata | Research Associate | Leslie |
| McGuffog | Lesley | Data Manager | McGuffog |
| Rae | Maureen | CCGE Group Administrator | Rae |
Teaching
Since 2010 Professor Antoniou has lectured on the MPhil in Epidemiology course and has been a member of the MPhil Admissions and Management committees since 2013. In 2016 he was appointed as the Academic Course Director for the Mphil in Epidemiology.
Selected Publications
Nyberg T, Frost D, Barrowdale D, …Easton DF, Antoniou AC. Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study Eur Urol. 2019 Sep 5. pii: S0302-2838(19)30675-X. doi: 10.1016/j.eururo.2019.08.025. [Epub ahead of print]
Lee A, Mavaddat N, Wilcox AN, Cunningham AP, Carver T, Hartley S, Babb de Villiers C, Izquierdo A, Simard J, Schmidt MK, Walter FM, Chatterjee N, Garcia-Closas M, Tischkowitz M, Pharoah P, Easton DF, Antoniou AC. BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors. Genet Med. 2019 doi: 10.1038/s41436-018-0406-9. Epub 2019 Jan 15.PMID:30643217
Kuchenbaecker KB, Hopper JL, Barnes DR … Antoniou AC (2017) Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA 2017 Jun 20; 317(23):2402-2416 PubMed ID: 28632866
Phelan CM, Kuchenbaecker KB… Antoniou AC*, Pharaoh PDP (2017) Identification of twelve new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017 May;49(5):680-691. doi: 10.1038/ng.3826. Epub 2017 Mar 27
PubMed ID: 28346442 *joint senior author
Lecarpentier J, Silvestri V, Kuchenbaecker KB, … Antoniou AC*, Ottini L (2017) Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using Polygenic Risk Scores. J Clin Oncol 2017 Jul 10;35(20):2240-2250
PubMed ID: 28448241 * joint senior author
Kuchenbaecker KB, Eccles D, …Antoniou AC et al (2017) Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 2017 Jul 1;109(7). PubMed ID 28376175
Vigorito E, Kuchenbaecker KB,…., Antoniou AC (2016), Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants that Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. PLoS One 2016 Jul 27;11(7):e0158801 PubMed ID: 27463617
Lawrenson K,…., Antoniou AC*, Gayther S* (2016) Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p13.1 Breast-Ovarian Cancer Susceptibility Locus Nat Commun 2016 Sep 7;7:12675 PubMed ID: 27601076 * Joint senior author
Couch FC, Kuchenbaecker, et al… Antoniou AC (2016). Identification of four novel susceptibility loci for estrogen receptor negative breast cancer. Nat Commun Apr 27;7:11375 PubMed ID: 27117709
Lee, A., et al… Antoniou AC (2016) Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model. Genetics In Medicine net Med. 2016 Apr 14. 2016 Dec;18(12):1190-1198. Pubmed ID: 27464310
Dunning A., et al … Antoniou AC*, Easton DF*, Edwards SL*(2016) Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170, Nature Genetics 48(4):374-86 PubMed ID: 26928228 *Joint senior author
Silvestri V, et al… Antoniou AC*, Ottini L* (2016) Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res. 2016 Feb 9;18(1):15 PubMed ID: 26857456 *Joint senior author
Ramus SJ, et al … (2015) Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J Natl Cancer Inst. 2015 Aug 27;107(11) PubMed ID: 26315354
Jervis, S.,et al… Antoniou AC (2015) A Risk Prediction Algorithm for Ovarian Cancer Incorporating BRCA1, BRCA2, Common Alleles and Other Familial Effects. J Med Genet 52: 465-75 PubMed ID: 26025000
Easton, D.F., et al… (2015) Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk. N Engl J Med Jun 4;372(23):2243-57 PubMed ID: 26014596
Rebbeck, T.R., et al… (2015) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA 313, 1347-1361 PubMed ID: 25849179
Kuchenbaecker, K.B., et al… Antoniou, AC*, and Chenevix-Trench, G.* (2015) Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature genetics 47, 164-171. PubMed ID: 25581431 *Joint senior author
Lee AJ, et al … (2013) BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface. Br J Cancer 110(2):535-45. PubMed ID: 24346285
Couch FJ, et al … (2013) Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk. PLOS Genetics (Mar;9(3):e1003212.)
Barnes DR, et al … (2012) Evaluation of Association Methods for Analysing Modifiers of Disease Risk in Carriers of High-Risk Mutations. Genet Epidemiol 36:274-91
Mulligan AM, et al … (2011) Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Br Cancer Res 13(6):R11
Loveday C, et al … (2011) RAD51D is an ovarian cancer predisposition gene. Nat Genet 43:879-82
Mcinnis RJ, et al … (2011) A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact. Genet Epidemiol 35:549-56
Antoniou AC, et al … (2010) Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res 70:9742-54
Antoniou AC, et al … (2010) A locus on 19p13 locus modifies risk of breast cancer for BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 42:174-91
Mavaddat N, et al … (2010) Incorporating tumour pathology information into breast cancer risk prediction algorithms. Breast Cancer Res 18;12(3):R28
Antoniou AC, et al … (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. Br J Cancer 98:1457-66