Data Manager

Email: ljm26@medschl.cam.ac.uk

Background

Lesley has been working as a data manager in the CCGE for a number of years after previously holding a similar position at the World Conservation Monitoring Centre in Cambridge. Initially working for Douglas Easton and subsequently for Antonis Antoniou, Lesley’s work has focused on data management for the Breast Cancer Linkage Consortium and in recent years the CIMBA Consortium for which she currently manages the primary database.

Research Interests

Breast and ovarian cancer risks in BRCA1/2 mutation carriers
BRCA1/2 mutation nomenclature

Selected Publications

Amos CI, et al. The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers.
Cancer Epidemiol Biomarkers Prev. 2016 Oct 3. pii: cebp.0106.2016. [Epub ahead of print]

Couch FJ, Kuchenbaecker KB, Michailidou K et al. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nat Commun. 2016 Apr 27;7:11375

Meeks HD, et al. BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.
J Natl Cancer Inst. 2015 Nov 19;108(2). pii: djv315

Hollestelle A, et al. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Gynecol Oncol. 2016 May;141(2):386-401

Rebbeck TR, et al. Association of Type and Location of BRCA1 and BRCA2 Mutations with Risk of Breast and Ovarian Cancer.
JAMA. 2015 Apr 7;313(13):1347-61

Kuchenbaecker KB, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Nat Genet. 2015 Feb;47(2):164-71

Spurdle AB, et al. Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.
Breast Cancer Res. 2014 Dec 23;16(6):3419

Kuchenbaecker KB, et al. Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.
Breast Cancer Res. 2014 Dec 31;16(6):3416

Gaudet MM, Kuchenbaecker KB, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
PLoS Genet. 2013;9(3):e1003173

Couch FJ, et al. Genome wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
PLoS Genet. 2013;9(3):e1003212