General practice offers rich and diverse opportunities to conduct clinical research – with excellent electronic records, access to nearly the entire population and staff who value evidence for practice. 43% of all those recruited to research in the East of England were recruited through General Practice in 2015/16. Because primary care is fragmented into thousands […]
The spectrum effect in tests for risk prediction, screening, and diagnosis
The importance of the spectrum effect Much of clinical practice relies on tests measuring one or more characteristics of an individual to determine whether that individual is at risk of developing a condition of interest or does or does not have a particular disease. Many scientists and clinicians are engaged in developing and/or choosing whether […]