|Title:||WRAP-UP: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP-UP): a cost-effectiveness analysis alongside a randomized controlled trial.|
The WRAP trial showed that behavioural weight loss programmes could be effective in the short-term to decrease people weight and, by doing so, mitigate the risk factors for some diseases, such as diabetes and cancers.
WRAP-UP is an extension study of WRAP, which aims to shed light on the long-term effects of the weight loss programmes investigated in WRAP and, thus, assess their cost-effectiveness.
Individuals with a body mass index of 28 kg/m2 or higher were randomised to either a weight-management programme or standard care, namely brief advice and self-help materials. The 5-year data on resource consumption, patients’ weight loss and their quality of life collected during WRAP-UP will be used to perform a cost-effectiveness analysis. The results of the within-trial cost-effectiveness analysis will be presented by incremental cost-effectiveness ratios, which will describe the incremental cost for 1 kg of weight loss alongside the incremental cost to obtain one additional QALY. A simulation study will extrapolate the within-trial results to assess whether the life-time effects of WRAP-UP programmes could represent good value for money for the NHS.
|Funder information:||National Institute for Health Research Programme Grants for Applied Research (NIHR RP-PG-0216-20010)|
|PPI/E involvement:||More information on taking part: http://www.mrc-epid.cam.ac.uk/take-part/study-contacts/|
|Start date:||1st January 2020|
|End date:||31st December 2021|
|Contact person:||Dr Amy Ahern, MRC Epidemiology Unit|
|PCU Contact:||Dr Francesco Fusco|
|Contact Details:||E-mail: firstname.lastname@example.org
|Further Information, References and Publications|