Title:	WRAP-UP: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP-UP): a cost-effectiveness analysis alongside a randomized controlled trial.
Project Description:	Background The WRAP trial showed that behavioural weight loss programmes could be effective in the short-term to decrease people weight and, by doing so, mitigate the risk factors for some diseases, such as diabetes and cancers. Aims WRAP-UP is an extension study of WRAP, which aims to shed light on the long-term effects of the weight loss programmes investigated in WRAP and, thus, assess their cost-effectiveness. Methods Individuals with a body mass index of 28 kg/m2 or higher were randomised to either a weight-management programme or standard care, namely brief advice and self-help materials. The 5-year data on resource consumption, patients’ weight loss and their quality of life collected during WRAP-UP will be used to perform a cost-effectiveness analysis. The results of the within-trial cost-effectiveness analysis will be presented by incremental cost-effectiveness ratios, which will describe the incremental cost for 1 kg of weight loss alongside the incremental cost to obtain one additional QALY. A simulation study will extrapolate the within-trial results to assess whether the life-time effects of WRAP-UP programmes could represent good value for money for the NHS.
Funder information:	National Institute for Health Research Programme Grants for Applied Research (NIHR RP-PG-0216-20010)
PPI/E involvement:	More information on taking part: http://www.mrc-epid.cam.ac.uk/take-part/study-contacts/
Project organisation
Start date:	1st January 2020
End date:	31st December 2021
Contact person:	Dr Amy Ahern,  MRC Epidemiology Unit
PCU Contact:	Dr Francesco Fusco
Contact Details:	E-mail: ff346@medschl.cam.ac.uk Website: http://www.mrc-epid.cam.ac.uk/research/studies/wrap/
Further Information, References and Publications