|Title:||Identifying patients at raised risk of stroke due to paroxysmal or persistent atrial fibrillation in primary care populations|
|Project Description:||About 25% of strokes are associated with atrial fibrillation (AF), and about 25% of people who have a stroke that is associated with AF only have the arrhythmia diagnosed at the time of their stroke. In relative terms, AF is associated with a fivefold increase in risk of stroke, and in absolute terms, AF is going to become an even more important cause of stroke in the future. However, while there have been advances in detection and treatment of AF in recent years, the National Screening Committee currently recommends against a screening program due to insufficient evidence of patient benefit.
We intend to undertake analyses to support the development of an NIHR programme grant application to determine whether screening for AF is cost effective. Our proposal is to use NSPCR funds to carry out key preliminary work using the Clinical Practice Research Datalink (CPRD) to address the following questions (which will inform the design of future studies to be included within the programme grant):
1. Is the prognosis of screen detected AF the same as clinically detected AF?
A retrospective cohort of patients will be created in CPRD; outcomes of patients with “screen detected” AF will be compared to other patients with AF (objectives 1, 2 and 3).
|Start date:||1st April 2016|
|End date:||31st October 2018|
|Contact person:||Dr Duncan Edwards|
|Contact Details:||Primary Care Unit
Strangeways Research Laboratory
Telephone: (01223) 330309
|Funding Organisation:||NIHR School for Primary Care Research|
|Funding Reference:||SPCR FR11|
|Further Information, References and Publications|
|Mendonca S, Saunders CL, Lung J, Mant J, Edwards D. Temporal trends in incidence of atrial fibrillation in primary care records. BMJ Open 2020; 10(12) e042518.|