| Title:
Project Description: |
Ovatools – Tests and tools for the detection of ovarian cancer in primary care: a CPRD study
Current UK guidance recommends that women presenting to primary care with symptoms of possible ovarian cancer be tested for the serum biomarker Cancer Antigen 125 (CA125). Yet, CA125 has never been evaluated in a primary care population. In this study, we will use routinely collected primary care data and cancer registry data from over 50,000 women to evaluate the diagnostic accuracy of CA125 in primary care. In addition, we will develop a prediction tool incorporating CA125 levels, symptoms and demographics to identify those women at greatest risk of having ovarian cancer. |
| Project organisation | |
| Start date: | 1st February 2019 |
| End date: | 1st November 2020 |
| Contact person: | Dr Garth Funston |
| Contact Details: | Strangeways Research Laboratory Worts Causeway Cambridge Cambs CB1 8RN UK Telephone: (01223) 7n/a Fax: E-mail: gf272@medschl.cam.ac.uk |
| Further Information, References and Publications | |
| Funston G, Abel G, Crosbie EJ, Hamilton W, Walter FM. Could Ovarian Cancer Prediction Models Improve the Triage of Symptomatic Women in Primary Care? A Modelling Study Using Routinely Collected Data. Cancers. 2021. https://doi.org/10.3390/cancers13122886
Funston G, Mounce LT, Price S, Rous B, Crosbie EJ, Hamilton W, Walter FM. CA125 test result, test-to-diagnosis interval and stage in ovarian cancer: a cohort study using electronic health records. British Journal of General Practice. 2021. http://dx.doi.org/10.3399/BJGP.2020.0859Funston G, Hamilton W, Abel G, Crosbie EJ, Rous B, Walter FM. The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study. PLoS medicine. 2020. https://doi.org/10.1371/journal.pmed.1003295 Funston G, Hardy V, Abel G, Crosbie EJ, Emery J, Hamilton W, Walter FM. Identifying Ovarian Cancer in Symptomatic Women: A Systematic Review of Clinical Tools. Cancers. 2020. https://doi.org/10.3390/cancers12123686 Funston G, Van Melle M, Baun ML, Jensen H, Helsper C, Emery J, Crosbie EJ, Thompson M, Hamilton W, Walter FM. Variation in the initial assessment and investigation for ovarian cancer in symptomatic women: a systematic review of international guidelines. BMC Cancer. 2019. https://doi.org/10.1186/s12885-019-6211-2 For more information visit https://www.phpc.cam.ac.uk/pcu/research/research-groups/cancer-group/ovarian-cancer/ |
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