| Title: | Barrett’s ESophagus Trial 3 |
| Project Description: | Early detection of oesophageal cancer has been shown to improve patient outcomes. However, most patients with heartburn (the primary risk factor) are not investigated and most cases of oesophageal cancer present at an advanced stage.
The BEST3 Trial will assess whether the newly-developed CytospongeTM –TFF3 (Trefoil Factor 3) test for patients with reflux symptoms will be effective in increasing the detection of Barrett’s oesophagus in primary care and to evaluate its cost effectiveness. It will give us further information on the diagnostic accuracy of the CytospongeTM -TFF3 test and will also evaluate the patient acceptability of this new diagnostic test. It is hoped that this research will establish whether the CytospongeTM -TFF3 test offers earlier detection and an alternative approach to invasive endoscopy. This will build on the previous multi-site BEST1 and BEST2 trials, providing the last step before this test could be adopted into mainstream practice in the UK. The trial will take 3 years to complete. |
| Project organisation | |
| Start date: | 1st March 2016 |
| End date: | 31st May 2019 |
| Contact person: | Dr Fiona Scheibl |
| Contact Details: | Primary Care Unit Institute of Public Health University Forvie Site, Robinson Way Cambridge Cambs CB2 0SR UK Telephone: (01223) 330323 Fax: 01223 762515 E-mail: fs220@medschl.cam.ac.uk |
| Collaborative: | Prof. Rebecca C Fitzgerald, MRC Cancer Unit at the University of Cambridge, Hutchison/MRC Research Centre, Honorary Consultant Gastroenterologist at Cambridge University Hospitals NHS Foundation Trust, Cambridge Clinical Trial Design and StatisticsProf Peter Sasieni, Wolfson Institute of Prevention and Barts Clinical Trials Unit, Queen Mary, University of LondonProf Greg Rubin, Newcastle University Prof Stephen Morris, Department of Applied Health Research, University College London |
| Funding information | |
| Funding Organisation: | Cancer Research UK (CRUK) |
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| Further Information, References and Publications | |
| Website : http://www.best3trial.org | |