CanRisk – risk stratified approaches to cancer prevention are of increasing interest for primary care.
Funded by Cancer Research UK, the CanRisk programme is exploring how genetic, lifestyle/hormonal and clinical risk factors can be combined to predict the likelihood of a person developing breast and/or ovarian cancer.
The main objective of the CanRisk programme is to use discoveries in cancer genomics and epidemiology to develop, validate and implement the CanRisk Tool (developed by the Centre for Cancer Genetic Epidemiology) for cancer risk-stratification and prevention in primary, secondary and tertiary care.
The CanRisk Tool incorporates the new version of BOADICEA, the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm. BOADICEA can be used to calculate the future risks of developing breast or ovarian cancer and the likelihood of carrying mutations in the moderate to high risk genes (e.g. BRCA1). You can read more about the BOADICEA model here.
Following the development of the prototype CanRisk Tool, The Primary Care Cancer Group completed evaluations in the primary care and specialist genetics settings. After validation, the CanRisk tool has undergone CE marking (November 2019) and is now available for use by healthcare professionals (register here https://canrisk.org/accounts/register/).
Although the tool is now being widely used in a variety of clinical settings all across the world, our evaluation identified that there were opportunities to further optimise the tool for use in primary care. As a result, The Primary Care Cancer Group is currently working on two projects that aim to refine the risk presentation formats and management guidance.
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For more information on CanRisk please contact: Stephanie Archer