| Title: | Preventative Role of a fixed dose combination Pill in Stroke |
| Project Description: | PROPS – A multi-centre, open-label, randomised controlled trial to test the non-inferiority of a fixed dose combination (FDC) pill strategy versus standard primary care for secondary prevention of stroke. Standard treatment for people who have suffered a stroke or mini-stroke (transient ischaemic attack, or TIA) usually includes taking blood pressure lowering medication, cholesterol lowering medication and aspirin. The aim of these treatments is to reduce the chance of having another stroke. Usually, these are all taken as separate tablets.PROPS is a clinical trial looking at two different ways of taking stroke medication, in a primary care setting. In this trial, these medicines have been combined together into one capsule called Trinomia. We want to find out whether taking the Trinomia capsule is at least as good as taking standard separate medications. This will tell us whether it has a role in the secondary prevention of vascular events (e.g. stroke or heart attack) in older people who have already had a stroke or TIA. The PROPS trial is part of a larger programme of research funded by the British Heart Foundation and the Stroke Association. The trial is sponsored by Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. |
| UK ISRCT Number: | 58452386 |
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| Start date: | 1st September 2015 |
| End date: | 31st March 2017 |
| Contact person: | Dr Kate Williams and Dr Merel Pannebakker |
| Contact Details: | Primary Care Unit Strangeways Research Laboratory Worts Causeway Cambridge Cambs CB1 8RN UK Telephone: (01223) 330332 Fax: E-mail: kmw36@medschl.cam.ac.uk or mmp32@medschl.cam.ac.uk |
| Collaborative: | University of Birmingham University of Oxford |
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| Funding Organisation: | British Heart Foundation |
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| Funding Organisation: | Stroke Association |
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| Further Information, References and Publications | |
| Trial website http://www.props.phpc.cam.ac.uk/The total funding amount of £999,818 is co-funded by the Stroke Association and the British Heart Foundation over a period of 60 months | |