In this prospective observational cohort study patients presenting with clinical signs and symptoms typical of CTS and in whom the diagnosis is confirmed by nerve conduction studies are invited to participate. Data on putative predictive factors are collected at baseline and follow-up through patient questionnaires and include standardised measures of symptom severity, hand function, psychological and physical health and quality of life. Resource use and cost over the 2 year period such as prescribed medications, primary, secondary and tertiary NHS and private healthcare are also collected through patient self-report at 6, 12, 18 and 24 months. The primary outcome used to classify treatment success or failures will be a 5-point global assessment of change. Secondary outcomes include changes in clinical symptoms, functioning, psychological health, quality of life and resource use. A multivariable model of factors which predict outcome and resource use will be developed.

This prospective cohort study will provide important data on the clinical course and costs of CTS over a two-year period and begin to identify predictive factors for treatment success from conservative and surgical interventions.