IMPORT-BCS - Assessing the potential impact of introducing risk stratification into the current English bowel screening programme - Primary Care Unit

Title:	IMPORT-BCS – Assessing the potential impact of introducing risk stratification into the current English bowel screening programme
Project Description:	The overall aim of this work is to assess the potential impact of introducing risk stratification using lifestyle or genomic information into the current English bowel screening programme. We will achieve this through three linked studies: An update of a previous systematic review to identify risk models which predict the future incidence of colorectal cancer and include genomic information External validation of the risk models identified in the systematic review in the UK Biobank cohort Impact and cost-effectiveness analysis to model the potential for population health and impact on the health service if risk stratification using the best performing lifestyle or genomic risk model was introduced into the English bowel screening programme
Funder information:	Bowel Cancer Research – £64,995
Other Collaborators:	Dr Catherine Saunders, University of Cambridge Professor Simon Griffin, University of Cambridge Dr Fiona Walter, University of Cambridge Professor Antonis Antoniou, University of Cambridge Dr Deborah Thompson, previously University of Cambridge Dr Chloe Thomas, University of Sheffield Dr Olena Mandrik, University of Sheffield Dr Sophie Whyte, University of Sheffield Professor Jon Emery, University of Melbourne Margaret Johnson, patient and public representative
Project organisation
Start date:	1st June 2018
End date:	31st May 2019
Contact person:	Dr Juliet Usher-Smith
Contact Details:	Email: jau20@medschl.cam.ac.uk
Further Information, References and Publications
Publications McGeoch L, Saunders CL, Griffin SJ, Emery J, Walter FM, Thompson D, Antoniou AC, Usher-Smith JA. Risk prediction models for colorectal cancer incorporating common genetic variants: a systematic review. Cancer Epidemiology Biomarkers and Prevention. 2019 pii: cebp.0059.2019. doi: 10.1158/1055-9965.EPI-19-0059 Saunders CL, Kilian B, Thompson D, Griffin SJ, Antoniou CA, Emery J, Walter FM, Usher-Smith JA. External validation of risk prediction models incorporating common genetic variants for incident colorectal cancer using UK Biobank. Cancer Prevention Research. 2020 13(6):509-520. doi: 10.1158/1940-6207.CAPR-19-0521 Thomas C, Mandrik O, Saunders CL, Griffin SJ, Whyte S, Usher-Smith JA. Should colorectal cancer screening start at different ages for men and women? Cost-effectiveness analysis for a resource constrained service Cancer Reports 2020 Feb 2:e1344. doi: 10.1002/cnr2.1344