A new study, recently published in Cancers, found that over one-quarter of bladder and kidney cancer patients who met NICE fast-track referral guidelines did not receive a timely diagnosis, suggesting that opportunities exist to improve timely referral. In England, patients with alarm features (symptoms and/or test results) of cancer should be assessed by a specialist […]
Biomarkers for the early detection of upper-gastrointestinal cancers in primary care: a systematic review
A new systematic review guided by the CanTest Framework found that while there is a large number of biomarkers being developed for the detection of upper GI cancers, more evidence from evaluations in low-prevalence populations like primary care is still needed before their adoption in clinical practice can be recommended. Cancers of the stomach, oesophagus, […]
Identifying Ovarian Cancer in Symptomatic Women: A Systematic Review of Clinical Tools
A new CanTest systematic review, just published in Cancers, found that several existing externally validated symptom-based tools have moderate diagnostic accuracy for ovarian cancer detection. The team concluded that the clinical impact of the most promising tools now needs to be evaluated. Ovarian cancer has the worst prognosis of all gynaecological cancers, accounting for over […]
Blood test predicts ovarian cancer better than previously thought
A blood test already available to GPs in the UK is more predictive of ovarian cancer than previously thought and could also help pick up other forms of cancer, according to new research published in PLOS Medicine and funded by Cancer Research UK and NIHR. This study was led by Dr Garth Funston at the […]
The BEST3 trial: is the Cytosponge TFF3 biomarker test oven-ready for primary care?
The Cytosponge test could help diagnosis of Barrett’s oesophagus in people who are on medication for long term heartburn. A clinical trial led by Prof Rebecca Fitzgerald in Cambridge was published on 1st August 2020 in The Lancet. Here, CanTest Chair Prof Greg Rubin, who contributed primary care expertise to the trial, explains more about the test and […]
Imaging activity possibly signalling missed diagnostic opportunities in bladder and kidney cancer: a longitudinal data-linkage study using primary care electronic health records
Blog by Dr Yin Zhou, Clinical Research Fellow, Cancer Group Patterns of events before the diagnosis of cancer may reveal ‘signals’ for missed diagnostic opportunities for patients. Earlier research, including from our CanTest collaborators in Denmark, has shown that increase in background rate of consultations, prescriptions and laboratory test use occur long before cancer diagnosis. […]
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