Submitted by sjc313 on Tue, 02/12/2025 - 14:16
Francisca Stutzin Donoso PhD, Department of Public Health and Primary Care
CanRisk is a risk assessment tool that uses the multifactorial BOADICEA breast cancer risk model. This model is recommended by the National Institute for Health and Care Excellence (NICE) for use in secondary and tertiary care settings across England, Wales, and Northern Ireland. BOADICEA integrates information on family history of cancer, demographic, lifestyle, hormonal risk factors, and mammographic density, alongside polygenic scores (PGS).
Introducing CanRisk within general practice may enable earlier identification of women at moderate or high risk of developing breast cancer, support improved management, and enhance the appropriateness of referrals to specialist services.
In this feasibility study, we will invite women aged 40–49 years from 5–8 general practices in Cambridgeshire and Peterborough, UK, to complete a breast cancer risk assessment using a newly developed public-facing version of CanRisk and to provide saliva samples for PGS testing. The study team will return a personalised risk report to participants and their GP.
Women found to have above-population risk will be encouraged to consult their GP for referral to clinical genetics, where they will be managed according to current NICE guidelines.
This study will evaluate the feasibility and acceptability of offering multifactorial cancer risk assessment in general practice, the ability of this approach to identify women at increased risk, and the costs of implementing proactive risk assessment in women under 50.
Read the full paper here: CanRisk-GP protocol: A feasibility study of incorporating proactive multifactorial breast cancer risk assessment into general practice | PLOS One