Researchers: Dr Allison Bentley (University of East Anglia), Dr Ben Bowers, Dr Caroline Barry (University of East Anglia), Isla Kuhn, Prof. Stephen Barclay
Funders: NIHR Applied Research Collaboration East of England
Partner institutions: University of East Anglia
Start date: 01/10/2024
End date: 31/03/2026
Project summary:
Parkinson’s disease and Lewy body dementia are progressive, incurable neurodegenerative conditions that most commonly affect older people. Prescribing antiemetics for these conditions can be particularly challenging at end of life, with several key antiemetics contraindicated in Parkinsons disease and Lewy body dementia. Our systematic review will explore the current evidence regarding end-of-life symptom control prescribing practices for nausea and vomiting for people with Parkinson’s disease and Lewy body dementia. We will synthesise the published evidence and identify where further research is needed.
PROSPERO details: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=560692
The review is currently being written up for publication.
Project aims:
This project aims to identify and synthesise the published evidence on the use of oral and parenteral dopamine receptor antagonist medications for the management of nausea and vomiting towards the end of life for people with Parkinson’s disease and Lewy body dementia.
Project impact:
This systematic review will highlight the key gaps in the current evidence to inform clinical practice and identify priority areas for future research.