Nag A, Dhindsa RS, Mitchell J, Vasavda C, Harper AR, Vitsios D, et al. Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes. Sci Adv. 2022 Nov 18;8(46):eadd5430.
Sollis E, Mosaku A, Abid A, Buniello A, Cerezo M, Gil L, et al. The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource. Nucleic Acids Res. 10.1093/nar/gkac1010
Foguet C, Xu Y, Ritchie SC, Lambert SA, Persyn E, Nath AP, et al. Genetically personalised organ-specific metabolic models in health and disease. Nat Commun. 2022 Nov 29;13(1):7356.
Butler-Laporte G, Povysil G, Kosmicki JA, Cirulli ET, Drivas T, Furini S, et al. Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative. PLoS Genet. 2022 Nov;18(11):e1010367.
Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, et al. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. Circulation. 2022 Nov 15;146(20):1507-17.
Pavey H, Kulkarni S, Wood A, Ben-Shlomo Y, Sever P, McEniery C, et al. Primary hypertension, anti-hypertensive medications and the risk of severe COVID-19 in UK Biobank. PLoS One. 2022;17(11):e0276781.
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, et al. Rare and common genetic determinants of metabolic individuality and their effects on human health. Nat Med. 2022 Nov;28(11):2321-32.
Jefferson E, Cole C, Mumtaz S, Cox S, Giles T, Adejumo S, et al. CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic. J Med Internet Res. 10.2196/40035
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Nov;611(7934):115-23.
Rodosthenous RS, Niemi MEK, Kallio L, Perala M, Terho P, Knopp T, et al. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen. BMJ Open. 2022 10 5;12(10):e064695.
Yuan S, Mason AM, Burgess S, Larsson SC. Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation. Diabetes. 2022 Oct 1;71(10):2222-32.
Khera AV, Wang M, Chaffin M, Emdin CA, Samani NJ, Schunkert H, et al. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circ Genom Precis Med. [published online: October 10, 2022]. 10.1161/CIRCGEN.121.003598
Batool F, Patel A, Gill D, Burgess S. Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization. Genet Epidemiol. 2022 10;46(7):415-29.
Ryan DK, Karhunen V, Su B, Traylor M, Richardson TG, Burgess S, et al. Genetic Evidence for Protective Effects of Angiotensin-Converting Enzyme Against Alzheimer Disease But Not Other Neurodegenerative Diseases in European Populations. Neurol Genet. 2022 Oct;8(5):e200014.
Busca E, Airoldi C, Bertoncini F, Buratti G, Casarotto R, Gaboardi S, et al. Bed rest duration and complications after transfemoral cardiac catheterization: a network meta-analysis. Eur J Cardiovasc Nurs. 10.1093/eurjcn/zvac098
Bleken Østergaard H, Hageman SHJ, Read SH, Taylor O, Pennells L, Kaptoge S, et al. Estimating individual lifetime risk of incident cardiovascular events in adults with type 2 diabetes: an update and geographical calibration of the DIAbetes Lifetime perspective model (DIAL2). Eur J Prev Cardiol. [published online: October 08, 2022].
Špacírová Z, Kaptoge S, García-Mochón L, Rodríguez Barranco M, Sánchez Pérez MJ, Bondonno NP, et al. The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease. Eur J Health Econ. [published online: October 14, 2022]. 10.1007/s10198-022-01533-y
Gkatzionis A, Burgess S, Newcombe PJ. Statistical methods for cis-Mendelian randomization with two-sample summary-level data. Genet Epidemiol. [published online: October 23, 2022]. 10.1002/gepi.22506
Chen L, Peters JE, Prins B, Persyn E, Traylor M, Surendran P, et al. Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke. Nat Commun. 2022 Oct 17;13(1):6143.
Carter P, Yuan S, Kar S, Vithayathil M, Mason AM, Burgess S, et al. Coffee consumption and cancer risk: a Mendelian randomisation study. Clin Nutr. [published online: August 25, 2022]. 10.1016/j.clnu.2022.08.019
Yuan S, Carter P, Mason AM, Yang F, Burgess S, Larsson SC. Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk. Arthritis Rheumatol. 2022 Oct;74(10):1638-47.
Knight R, Walker V, Ip S, Cooper JA, Bolton T, Keene S, et al. Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales. Circulation. 2022 Sep 20;146(12):892-906.
Paranjpe MD, Chaffin M, Zahid S, Ritchie S, Rotter JI, Rich SS, et al. Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease. PLoS Genet. 2022 09;18(9):e1010294.
Zhao JV, Burgess S, Fan B, Schooling CM. L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study. BMC Med. 2022 09 1;20(1):272.
Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, et al. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nat Genet. 2022 09;54(9):1332-44.
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, et al. Circulating vitamin C and digestive system cancers: Mendelian randomization study. Clin Nutr. 2022 Sep;41(9):2031-5.
Wiggins KA, Pyrillou K, Humphry M, Butterworth AS, Clarke MC. The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells. Immunology. [published online: September 29, 2022]. 10.1111/imm.13584
Yuan S, Mason AM, Titova OE, Vithayathil M, Kar S, Chen J, et al. Morning chronotype and digestive tract cancers: Mendelian randomization study. Int J Cancer. [published online: September 12, 2022]. 10.1002/ijc.34284
Paranjpe MD, Chaffin M, Zahid S, Ritchie S, Rotter JI, Rich SS, et al. Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease. PLoS Genet. 2022 Sep;18(9):e1010294.
Zhou F, Butterworth AS, Asimit JL. Flashfm-ivis: interactive visualization for fine-mapping of multiple quantitative traits. Bioinformatics. 2022 Sep 2;38(17):4238-42.
Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, et al. Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study. Eur J Prev Cardiol. 2022 Sep 7;29(12):1618-29.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet. 2022 08 4;109(8):1366-87.
Lemmelä S, Wigmore EM, Benner C, Havulinna AS, Ong RMY, Kempf T, et al. Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans. Elife. 2022 08 2;11:e76272.
Huang QQ, Sallah N, Dunca D, Trivedi B, Hunt KA, Hodgson S, et al. Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals. Nat Commun. 2022 08 9;13(1):4664.
Kotecha D, Asselbergs FW, Achenbach S, Anker SD, Atar D, Baigent C, et al. CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research. Lancet Digit Health. [published online: August 26, 2022]. 10.1016/S2589-7500(22)00151-0
Lopez-Jimenez F, Almahmeed W, Bays H, Cuevas A, Di Angelantonio E, le Roux CW, et al. Obesity and cardiovascular disease: mechanistic insights and management strategies. A joint position paper by the World Heart Federation and World Obesity Federation. Eur J Prev Cardiol. [published online: August 25, 2022]. 10.1093/eurjpc/zwac187
Sadique Z, Willis S, Corte K, Pennington M, Moore C, Kaptoge S, et al. Cost-effectiveness of alternative minimum recall intervals between whole blood donations. PLoS One. 2022;17(8):e0272854.
Matsushita K, Kaptoge S, Hageman SH, Sang Y, Ballew SH, Grams ME, et al. Including Measures of Chronic Kidney Disease to Improve Cardiovascular Risk Prediction by SCORE2 and SCORE2-OP. Eur J Prev Cardiol. [published online: August 16, 2022]. 10.1093/eurjpc/zwac176
Allara E, Lee WH, Burgess S, Larsson SC. Genetically predicted cortisol levels and risk of venous thromboembolism. PLoS One. 2022;17(8):e0272807.
Georgakis MK, Malik R, Richardson TG, Howson JMM, Anderson CD, Burgess S, et al. Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups. BMC Med. 2022 08 11;20(1):245.
Kar SP, Quiros PM, Gu M, Jiang T, Mitchell J, Langdon R, et al. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nat Genet. 2022 Aug;54(8):1155-66.
Larsson SC, Burgess S. Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies. EBioMedicine. 2022 Aug;82:104154.
Mayerhofer E, Malik R, Parodi L, Burgess S, Harloff A, Dichgans M, et al. Genetically predicted on-statin LDL response is associated with higher intracerebral haemorrhage risk. Brain. 2022 Aug 27;145(8):2677-86.
Topiwala A, Taschler B, Ebmeier KP, Smith S, Zhou H, Levey DF, et al. Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects. Mol Psychiatry. [published online: July 26, 2022]. 10.1038/s41380-022-01690-9
Hao Y, Xiao J, Liang Y, Wu X, Zhang H, Xiao C, et al. Reassessing the causal role of obesity in breast cancer susceptibility: a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure. Int J Epidemiol. [published online: July 15, 2022]. 10.1093/ije/dyac143
Xu Z, Arnold M, Sun L, Stevens D, Chung R, Ip S, et al. Incremental value of risk factor variability for cardiovascular risk prediction in individuals with type 2 diabetes: results from UK primary care electronic health records. Int J Epidemiol. 10.1093/ije/dyac140
Topiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, et al. Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses. PLoS Med. 2022 07;19(7):e1004039.
Thygesen JH, Tomlinson C, Hollings S, Mizani MA, Handy A, Akbari A, et al. COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records. Lancet Digit Health. 2022 07;4(7):e542-e557.
Zheng J, Xu M, Walker V, Yuan J, Korologou-Linden R, Robinson J, et al. Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomisation study. Diabetologia. [published online: July 29, 2022].
Coscia C, Gill D, Benítez R, Pérez T, Malats N, Burgess S. Avoiding collider bias in Mendelian randomization when performing stratified analyses. Eur J Epidemiol. 2022 Jul;37(7):671-82.
Dubé MP, Chazara O, Lemaçon A, Asselin G, Provost S, Barhdadi A, et al. Pharmacogenomic study of heart failure and candesartan response from the CHARM programme. ESC Heart Fail. [published online: June 23, 2022]. 10.1002/ehf2.14026
van Daalen KR, Kallesøe SS, Davey F, Dada S, Jung L, Singh L, et al. Extreme events and gender-based violence: a mixed-methods systematic review. Lancet Planet Health. 2022 Jun;6(6):e504-e523.
Moksnes MR, Graham SE, Wu KH, Hansen AF, Gagliano Taliun SA, Zhou W, et al. Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT. Commun Biol. 2022 Jun 16;5(1):591.
Burgess S, Chirinos JA, Damrauer SM, Gill D. Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis. Circ Genom Precis Med. 2022 Jun;15(3):e003575.
Bomba L, Walter K, Guo Q, Surendran P, Kundu K, Nongmaithem S, et al. Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites. Am J Hum Genet. 2022 Jun 2;109(6):1038-54.