Key Publications 2018
Webster AP, Plant D, Ecker S, Zufferey F, Bell JT, Feber A, et al. Increased DNA methylation variability in rheumatoid arthritis discordant monozygotic twins. 2018 May 4 [cited 2018 Jun 21]; Available from: http://biorxiv.org/lookup/doi/10.1101/314963
Tuijnenburg P, Lango Allen H, Burns SO, Greene D, Jansen MH, Staples E, et al. Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans. Journal of Allergy and Clinical Immunology [Internet]. 2018 Mar [cited 2018 Jun 14]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S0091674918302860
Teschendorff A, Han J, Paul D, Virta J, Nordhausen K. Tensorial Blind Source Separation for Improved Analysis of Multi-Omic Data. 2018 May 11 [cited 2018 Jun 14]; Available from: http://biorxiv.org/lookup/doi/10.1101/300277
Sun Y-Q, Brumpton BM, Bonilla C, Lewis SJ, Burgess S, Skorpen F, et al. Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study. European Respiratory Journal. 2018 Jun;51(6):1800329.
Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, et al. Genomic atlas of the human plasma proteome. Nature. 2018 Jun;558(7708):73–9.
Schooling CM, Luo S, Au Yeung SL, Thompson DJ, Karthikeyan S, Bolton TR, et al. Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation. International Journal of Cardiology [Internet]. 2018 May [cited 2018 Jun 14]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S0167527317361016
Ricci C, Wood A, Muller D, Gunter MJ, Agudo A, Boeing H, et al. Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study. BMJ. 2018 May 29;k934.
Powell JT, Sweeting MJ, Ulug P, Thompson MM, Hinchliffe RJ. Editor’s Choice – Re-interventions After Repair of Ruptured Abdominal Aortic Aneurysm: A Report From the IMPROVE Randomised Trial. European Journal of Vascular and Endovascular Surgery. 2018 May;55(5):625–32.
Peters JE, Gupta V, Saeed IT, Offiah C, Jawad ASM. Severe localised granulomatosis with polyangiitis (Wegener’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. BMC Neurology [Internet]. 2018 Dec [cited 2018 Jun 14];18(1). Available from: https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-018-1058-8
Patel R, Powell JT, Sweeting MJ, Epstein DM, Barrett JK, Greenhalgh RM. The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up and cost-effectiveness analysis. Health Technology Assessment. 2018 Jan;22(5):1–132.
Paige E, Barrett J, Stevens D, Keogh RH, Sweeting MJ, Nazareth I, et al. Landmark Models for Optimizing the Use of Repeated Measurements of Risk Factors in Electronic Health Records to Predict Future Disease Risk. American Journal of Epidemiology [Internet]. 2018 Mar 23 [cited 2018 Jun 14]; Available from: https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwy018/4952104
Oliver-Williams C, Sweeting MJ, Turton G, Parkin D, Cooper D, Rodd C, et al. Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme. British Journal of Surgery. 2018 Jan;105(1):68–74.
O’Keeffe LM, Ramond A, Oliver-Williams C, Willeit P, Paige E, Trotter P, et al. Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis. Annals of Internal Medicine. 2018 Feb 20;168(4):276.
McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, et al. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A 2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis. 2018 Feb;269:42–9.
Mayer L, Jasztal M, Pardo M, Aguera de Haro S, Collins J, Bariana TK, et al. Nbeal2 interacts with Dock7, Sec16a, and Vac14. Blood. 2018 Mar 1;131(9):1000–11.
Martin RM, Donovan JL, Turner EL, Metcalfe C, Young GJ, Walsh EI, et al. Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial. JAMA. 2018 Mar 6;319(9):883.
Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I, et al. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration. Pirro M, editor. PLOS ONE. 2018 Apr 12;13(4):e0191172.
Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, et al. Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population. Circulation. 2018 Apr 30;CIRCULATIONAHA.117.032047.
Lassale C, Tzoulaki I, Moons KGM, Sweeting M, Boer J, Johnson L, et al. Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis. European Heart Journal. 2018 Feb 1;39(5):397–406.
Larsson SC, Burgess S, Michaëlsson K. Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study. BMC Medicine [Internet]. 2018 Dec [cited 2018 Jun 14];16(1). Available from: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1065-z
Lane WJ, Westhoff CM, Gleadall NS, Aguad M, Smeland-Wagman R, Vege S, et al. Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study. The Lancet Haematology. 2018 Jun;5(6):e241–51.
Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, et al. New prospects for PCSK9 inhibition? European Heart Journal [Internet]. 2018 Mar 22 [cited 2018 Jun 14]; Available from: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehy147/4951530
Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, et al. 2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia. European Heart Journal. 2018 Apr 7;39(14):1131–43.
Kunutsor SK, Laukkanen JA, Burgess S. Genetically elevated gamma-glutamyltransferase and Alzheimer’s disease. Experimental Gerontology. 2018 Jun;106:61–6.
Knott CS, Bell S, Britton A. The stability of baseline-defined categories of alcohol consumption during the adult life-course: a 28-year prospective cohort study: Stability of baseline consumption categories. Addiction. 2018 Jan;113(1):34–43.
Knott CS, Britton A, Bell S. Trajectories of alcohol consumption prior to the diagnosis of type 2 diabetes: a longitudinal case–cohort study. International Journal of Epidemiology [Internet]. 2018 Jan 12 [cited 2018 Jun 14]; Available from: http://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyx274/4803218
Khandaker GM, Zammit S, Burgess S, Lewis G, Jones PB. Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. Brain, Behavior, and Immunity. 2018 Mar;69:264–72.
Jiang X, O’Reilly PF, Aschard H, Hsu Y-H, Richards JB, Dupuis J, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications [Internet]. 2018 Dec [cited 2018 Jun 14];9(1). Available from: http://www.nature.com/articles/s41467-017-02662-2
Holt KE, McAdam P, Thai PVK, Thuong NTT, Ha DTM, Lan NN, et al. Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam. Nature Genetics. 2018 Jun;50(6):849–56.
Hemingway H, Asselbergs FW, Danesh J, Dobson R, Maniadakis N, Maggioni A, et al. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential. European Heart Journal. 2018 Apr 21;39(16):1481–95.
Harrison SC, Holmes MV, Burgess S, Asselbergs FW, Jones GT, Baas AF, et al. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis. JAMA Cardiology. 2018 Jan 1;3(1):26.
Glover MJ, Jones E, Masconi KL, Sweeting MJ, Thompson SG, SWAN Collaborators, et al. Discrete Event Simulation for Decision Modeling in Health Care: Lessons from Abdominal Aortic Aneurysm Screening. Medical Decision Making. 2018 May;38(4):439–51.
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, et al. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 2018 Jan 23;5:180002.
Ference BA. Causal Effect of Lipids and Lipoproteins on Atherosclerosis. Cardiology Clinics. 2018 May;36(2):203–11.
Ference BA. How to use Mendelian randomization to anticipate the results of randomized trials. European Heart Journal. 2018 Feb 1;39(5):360–2.
ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Mahajan A, Wessel J, Willems SM, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics. 2018 Apr;50(4):559–71.
Evans JDW, Dobbin SJH, Pettit SJ, Di Angelantonio E, Willeit P. High-Sensitivity Cardiac Troponin and New-Onset Heart Failure. JACC: Heart Failure. 2018 Mar;6(3):187–97.
Emdin CA, Khera AV, Chaffin M, Klarin D, Natarajan P, Aragam K, et al. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nature Communications [Internet]. 2018 Dec [cited 2018 Jun 14];9(1). Available from: http://www.nature.com/articles/s41467-018-03911-8
Ecker S, Pancaldi V, Valencia A, Beck S, Paul DS. Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity. BioEssays. 2018 Feb;40(2):1700148.
Di Angelantonio E. Body mass index as a measure of global adiposity. Archives of Cardiovascular Diseases. 2018 Mar;111(3):141–3.
Corbin LJ, Tan VY, Hughes DA, Wade KH, Paul DS, Tansey KE, et al. Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. Nature Communications [Internet]. 2018 Dec [cited 2018 Jun 14];9(1). Available from: http://www.nature.com/articles/s41467-018-03109-y
Colpani V, Baena CP, Jaspers L, van Dijk GM, Farajzadegan Z, Dhana K, et al. Lifestyle factors, cardiovascular disease and all-cause mortality in middle-aged and elderly women: a systematic review and meta-analysis. European Journal of Epidemiology [Internet]. 2018 Mar 10 [cited 2018 Jun 14]; Available from: http://link.springer.com/10.1007/s10654-018-0374-z
CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics. 2018 Jan;50(1):26–41.
Burgess S, Zuber V, Gkatzionis A, Foley CN. Modal-based estimation via heterogeneity-penalized weighting: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid. International Journal of Epidemiology [Internet]. 2018 May 26 [cited 2018 Jun 14]; Available from: https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyy080/5011821
Burgess S, Foley CN, Zuber V. Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data. Annual Review of Genomics and Human Genetics [Internet]. 2018 Aug 31 [cited 2018 Jun 14];19(1). Available from: http://www.annualreviews.org/doi/10.1146/annurev-genom-083117-021731
Blue Mountains Eye Study—GWAS group, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Iglesias AI, Mishra A, Vitart V, et al. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nature Communications [Internet]. 2018 Dec [cited 2018 Jun 14];9(1). Available from: http://www.nature.com/articles/s41467-018-03646-6
Bédard A, Lewis SJ, Burgess S, Henderson AJ, Shaheen SO. Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study. BMJ Open Respiratory Research. 2018 Mar;5(1):e000275.
Batty GD, Kivimäki M, Bell S, Gale CR, Shipley M, Whitley E, et al. Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies. Translational Psychiatry [Internet]. 2018 Dec [cited 2018 Jun 14];8(1). Available from: http://www.nature.com/articles/s41398-017-0072-8
Batty GD, Bell S. Animal Companionship and Risk of Suicide: Epidemiology. 2018 Jul;29(4):e25–6.
AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, BioBank Japan Cooperative Hospital Group, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. 2018 Apr;50(4):524–37.