Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, et al. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. Schulz C, editor. PLOS ONE. 2017 May 23;12(5):e0178095.
Zilanawala A, Abell J, Bell S, Webb E, Lacey R. Parental nonstandard work schedules during infancy and children’s BMI trajectories. Demographic Research. 2017 Sep 19;37:709–26.
Zhao W, Rasheed A, Tikkanen E, Lee J-J, Butterworth AS, Howson JMM, et al. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nature Genetics. 2017 Sep 4;49(10):1450–7.
Zanetti D, Tikkanen E, Gustafsson S, Priest JR, Burgess S, Ingelsson E. Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization. 2017 Oct 25 [cited 2018 Jun 14]; Available from: http://biorxiv.org/lookup/doi/10.1101/208629
Yavorska OO, Burgess S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. International Journal of Epidemiology. 2017 Dec 1;46(6):1734–9.
Willeit P, Welsh P, Evans JDW, Tschiderer L, Boachie C, Jukema JW, et al. High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants. Journal of the American College of Cardiology. 2017 Aug;70(5):558–68.
Wheeler GM, Sweeting MJ, Mander AP. Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials: TOXICITY-DEPENDENT FEASIBILITY BOUNDS FOR PHASE I TRIALS. Statistics in Medicine. 2017 Jul 20;36(16):2499–513.
Wheeler GM, Sweeting MJ, Mander AP, Lee SM, Cheung YKK. Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration: Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration. Statistics in Medicine. 2017 Jan 30;36(2):225–41.
Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NGD, Jansen H, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology. 2017 Feb;69(7):823–36.
Webb EA, Bell S, Lacey RE, Abell JG. Crossing the road in time: Inequalities in older people’s walking speeds. Journal of Transport & Health. 2017 Jun;5:77–83.
Walker VM, Davies NM, Windmeijer F, Burgess S, Martin RM. Power calculator for instrumental variable analysis in pharmacoepidemiology. International Journal of Epidemiology. 2017 Oct 1;46(5):1627–32.
Understanding Society Scientific Group, EPIC-CVD Consortium, UK10K Consortium, Hendricks AE, Bochukova EG, Marenne G, et al. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. Scientific Reports [Internet]. 2017 Dec [cited 2018 Jun 14];7(1). Available from: http://www.nature.com/articles/s41598-017-03054-8
Ulug P, Sweeting MJ, von Allmen RS, Thompson SG, Powell JT, Ulug P, et al. Morphological suitability for endovascular repair, non-intervention rates, and operative mortality in women and men assessed for intact abdominal aortic aneurysm repair: systematic reviews with meta-analysis. The Lancet. 2017 Jun;389(10088):2482–91.
Tom BDM, Thompson SG, Duffy SW, Sweeting MJ, Ohlssen DI. Richard Nixon, 1972-2016. Journal of the Royal Statistical Society: Series A (Statistics in Society). 2017 Jun;180(3):932–3.
Thompson S. Sources of evidence for assessing the safety, efficacy and effectiveness of medicines [Internet]. Academy of Medical Sciences; 2017 Jun. Available from: https://acmedsci.ac.uk/policy/policy-projects/methods-of-evaluating-evidence
The UK-PSC Consortium, The International IBD Genetics Consortium, The International PSC Study Group, Ji S-G, Juran BD, Mucha S, et al. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics. 2017 Feb;49(2):269–73.
The Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, et al. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncology. 2017 May 1;3(5):636.
The International Consortium of Blood Pressure (ICBP) 1000G Analyses, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific group, The CHD Exome+ Consortium, The ExomeBP Consortium, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics. 2017 Mar;49(3):403–15.
Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J, Walter K, et al. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. The American Journal of Human Genetics. 2017 Jun;100(6):865–84.
Sweeting MJ. Development, evaluation (including randomised controlled trial and economic evaluation) and implementation of a web-based self-management programme for people with type 2 diabetes (HeLP-Diabetes). 2017 Dec 4 [cited 2018 Jun 14]; Available from: https://www.repository.cam.ac.uk/handle/1810/269892
Sweeting MJ, Patel R, Powell JT, Greenhalgh RM. Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair: Very Long-term Follow-up in the EVAR-2 Randomized Controlled Trial. Annals of Surgery. 2017 Nov;266(5):713–9.
Sweeting MJ, Barrett JK, Thompson SG, Wood AM. The use of repeated blood pressure measures for cardiovascular risk prediction: a comparison of statistical models in the ARIC study: REPEATED BLOOD PRESSURE MEASURES FOR CVD RISK PREDICTION. Statistics in Medicine. 2017 Dec 10;36(28):4514–28.
Sweeting MJ. Using predictions from a joint model for longitudinal and survival data to inform the optimal time of intervention in an abdominal aortic aneurysm screening programme. Biometrical Journal. 2017 Nov;59(6):1247–60.
Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. Journal of the American College of Cardiology. 2017 Apr;69(16):2054–63.
Staley JR, Burgess S. Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to Mendelian randomization. Genetic Epidemiology. 2017 May;41(4):341–52.
Staley JR, Jones E, Kaptoge S, Butterworth AS, Sweeting MJ, Wood AM, et al. A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design. European Journal of Human Genetics. 2017 Jun;25(7):854–62.
Song C, Burgess S, Eicher JD, O’Donnell CJ, Johnson AD. Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. Journal of the American Heart Association. 2017 Jun;6(6):e004918.
Sofianopoulou E, Pless-Mulloli T, Rushton S, Diggle P. Modelling seasonal and spatio-temporal variation in respiratory prescribing: the example of respiratory prescribing. 2017 Feb 8;
Sivapalaratnam S, Westbury SK, Stephens JC, Greene D, Downes K, Kelly AM, et al. Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia. Blood. 2017 Jan 26;129(4):520–4.
Sidloff DA, Saratzis A, Sweeting MJ, Michaels J, Powell JT, Thompson SG, et al. Sex differences in mortality after abdominal aortic aneurysm repair in the UK: Sex differences in mortality after abdominal aortic aneurysm repair. British Journal of Surgery. 2017 Nov;104(12):1656–64.
Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. The Lancet Neurology. 2017 Nov;16(11):898–907.
Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 Apr 12;544(7649):235–9.
Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, et al. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. The Lancet Diabetes & Endocrinology. 2017 Jul;5(7):524–33.
Rossi SH, Hsu R, Blick C, Goh V, Nathan P, Nicol D, et al. Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography. British Journal of Surgery. 2017 May;104(6):648–59.
Rees JMB, Wood AM, Burgess S. Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy. Statistics in Medicine. 2017 Dec 20;36(29):4705–18.
Powell JT, Sweeting MJ, Ulug P, Blankensteijn JD, Lederle FA, Becquemin J-P, et al. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal of Surgery. 2017 Feb;104(3):166–78.
Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, et al. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Journal of Clinical Investigation. 2017 Jan 30;127(3):814–29.
Petersen R, Lambourne JJ, Javierre BM, Grassi L, Kreuzhuber R, Ruklisa D, et al. Platelet function is modified by common sequence variation in megakaryocyte super enhancers. Nature Communications. 2017 Jul 13;8:16058.
Paige E, Masconi KL, Tsimikas S, Kronenberg F, Santer P, Weger S, et al. Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature. Cardiovascular Diabetology [Internet]. 2017 Dec [cited 2018 Jun 21];16(1). Available from: http://cardiab.biomedcentral.com/articles/10.1186/s12933-017-0520-z
Paige E, Barrett J, Pennells L, Sweeting M, Willeit P, Di Angelantonio E, et al. Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. American Journal of Epidemiology. 2017 Oct 15;186(8):899–907.
Obeidat M, Li X, Burgess S, Zhou G, Fishbane N, Hansel NN, et al. Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation. European Respiratory Journal. 2017 Nov;50(5):1700657.
O’Neill D, Britton A, Brunner EJ, Bell S. Twenty‐Five‐Year Alcohol Consumption Trajectories and Their Association With Arterial Aging: A Prospective Cohort Study. Journal of the American Heart Association. 2017 Feb;6(2):e005288.
Nomura A, Won H-H, Khera AV, Takeuchi F, Ito K, McCarthy S, et al. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart DiseaseNovelty and Significance. Circulation Research. 2017 Jun 23;121(1):81–8.
Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nature Genetics. 2017 Jul 17;49(9):1385–91.
Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, et al. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention SettingClinical Perspective. Circulation. 2017 May 30;135(22):2091–101.
Muka T, Chowdhury R, Franco OH. Effect of Iron Levels on Women After Premature or Early-Onset Menopause—Reply. JAMA Cardiology. 2017 Apr 1;2(4):458.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017 Feb 1;542(7640):186–90.
Liu Z, Burgess S, Wang Z, Deng W, Chu X, Cai J, et al. Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis. Scientific Reports. 2017 Jan 30;7:41579.
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics. 2017 Oct 30;49(12):1758–66.
Larsson SC, Traylor M, Burgess S, Markus HS. Genetically-Predicted Adult Height and Alzheimer’s Disease. Journal of Alzheimer’s Disease. 2017 Sep 18;60(2):691–8.
Larsson SC, Burgess S, Michaëlsson K. Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction. JAMA. 2017 Jul 25;318(4):371.
Lacey RE, Sacker A, Bell S, Kumari M, Worts D, McDonough P, et al. Work-family life courses and BMI trajectories in three British birth cohorts. International Journal of Obesity. 2017 Feb;41(2):332–9.
Kunutsor SK, Kieneker LM, Burgess S, Bakker SJL, Dullaart RPF. Circulating Total Bilirubin and Future Risk of Hypertension in the General Population: The Prevention of Renal and Vascular End‐Stage Disease (PREVEND) Prospective Study and a Mendelian Randomization Approach. Journal of the American Heart Association. 2017 Nov;6(11):e006503.
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, et al. New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCLINICAL PERSPECTIVE. Circulation: Cardiovascular Genetics. 2017 Oct;10(5):e001778.
Khera AV, Won H-H, Peloso GM, O’Dushlaine C, Liu D, Stitziel NO, et al. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 Mar 7;317(9):937.
Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 2017 Dec 19;4:170179.
Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, et al. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. New England Journal of Medicine. 2017 Jul 13;377(2):111–21.
Howson JMM, Zhao W, Barnes DR, Ho W-K, Young R, Paul DS, et al. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nature Genetics. 2017 May 22;49(7):1113–9.
Harrison JM, Gilchrist PT, Corovic TS, Bogetti C, Song Y, Bacon SL, et al. Respiratory and hemodynamic contributions to emotion-related pre-syncopal vasovagal symptoms. Biological Psychology. 2017 Jul;127:46–52.
Guo Q, Et A. Body Mass Index and Breast Cancer Survival: A Mendelian Randomisation Analysis. 2017 Jun 15 [cited 2018 Jun 14]; Available from: https://www.repository.cam.ac.uk/handle/1810/264773
Gunter MJ, Murphy N, Cross AJ, Dossus L, Dartois L, Fagherazzi G, et al. Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study. Annals of Internal Medicine. 2017 Aug 15;167(4):236.
Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, et al. Genetic invalidation of Lp-PLA 2 as a therapeutic target: Large-scale study of five functional Lp-PLA 2 -lowering alleles. European Journal of Preventive Cardiology. 2017 Mar;24(5):492–504.
Goldman M, Steele WR, Di Angelantonio E, van den Hurk K, Vassallo RR, Germain M, et al. Comparison of donor and general population demographics over time: a BEST Collaborative group study: DONOR AND GENERAL POPULATION DEMOGRAPHICS. Transfusion. 2017 Oct;57(10):2469–76.
Gage SH, Jones HJ, Taylor AE, Burgess S, Zammit S, Munafò MR. Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization. Scientific Reports. 2017 Jan 19;7:40653.
Gage SH, Jones HJ, Burgess S, Bowden J, Davey Smith G, Zammit S, et al. Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychological Medicine. 2017 Apr;47(05):971–80.
Franceschini N, Fry RC, Balakrishnan P, Navas-Acien A, Oliver-Williams C, Howard AG, et al. Cadmium body burden and increased blood pressure in middle-aged American Indians: the Strong Heart Study. Journal of Human Hypertension. 2017 Mar;31(3):225–30.
Ference BA, Kastelein JJP, Ginsberg HN, Chapman MJ, Nicholls SJ, Ray KK, et al. Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. JAMA. 2017 Sep 12;318(10):947.
Feber A, Dhami P, Dong L, de Winter P, Tan WS, Martínez-Fernández M, et al. UroMark—a urinary biomarker assay for the detection of bladder cancer. Clinical Epigenetics [Internet]. 2017 Dec [cited 2018 Jun 14];9(1). Available from: http://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-016-0303-5
Farahi N, Paige E, Balla J, Prudence E, Ferreira RC, Southwood M, et al. Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. Human Molecular Genetics. 2017 Apr 15;26(8):1584–96.
Ewing G, Penfold C, Benson JA, Mahadeva R, Howson S, Burkin J, et al. Clinicians’ Views of Educational Interventions for Carers of Patients With Breathlessness Due to Advanced Disease: Findings From an Online Survey. Journal of Pain and Symptom Management. 2017 Feb;53(2):265–71.
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, et al. Genetic analysis of over one million people identifies 535 novel loci for blood pressure. 2017 Oct 11 [cited 2018 Jun 14]; Available from: http://biorxiv.org/lookup/doi/10.1101/198234
Di Angelantonio E, Thompson SG, Kaptoge S, Moore C, Walker M, Armitage J, et al. Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors. The Lancet. 2017 Nov;390(10110):2360–71.
Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, et al. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. Genome Biology [Internet]. 2017 Dec [cited 2018 Jun 21];18(1). Available from: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1173-7
Burgess S, Zuber V, Valdes-Marquez E, Sun BB, Hopewell JC. Mendelian randomization with fine-mapped genetic data: Choosing from large numbers of correlated instrumental variables. Genetic Epidemiology. 2017 Dec;41(8):714–25.
Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. European Journal of Epidemiology. 2017 May;32(5):377–89.
Burgess S, Thompson DJ, Rees JMB, Day FR, Perry JR, Ong KK. Dissecting Causal Pathways Using Mendelian Randomization with Summarized Genetic Data: Application to Age at Menarche and Risk of Breast Cancer. Genetics. 2017 Aug 23;genetics.300191.2017.
Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for Mendelian randomization. Statistical Methods in Medical Research. 2017 Oct;26(5):2333–55.
Burgess S, Davey Smith G. Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol–Associated Mechanisms in Etiology of Age-Related Macular Degeneration. Ophthalmology. 2017 Aug;124(8):1165–74.
Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG. Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants: Epidemiology. 2017 Jan;28(1):30–42.
Britton A, Bell S. The protective effects of moderate drinking: lies, damned lies, and… selection biases?: Commentaries. Addiction. 2017 Feb;112(2):218–9.
Bowden J, Burgess S, Smith GD. Difficulties in Testing the Instrument Strength Independent of Direct Effect Assumption in Mendelian Randomization. JAMA Cardiology. 2017 Aug 1;2(8):929.
BLUEPRINT Consortium, Ecker S, Chen L, Pancaldi V, Bagger FO, Fernández JM, et al. Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. Genome Biology [Internet]. 2017 Dec [cited 2018 Jun 21];18(1). Available from: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1156-8
Bhupathiraju SN, Di Angelantonio E, Danesh J, Hu FB. Commentary on “A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration.” Journal of Clinical Epidemiology. 2017 Aug;88:30–2.
Bell S, Daskalopoulou M, Rapsomaniki E, George J, Britton A, Bobak M, et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;j909.
Bell S, Mehta G, Moore K, Britton A. Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study. Journal of Internal Medicine. 2017 Jan;281(1):75–85.
Barrett J, Su L. Dynamic predictions using flexible joint models of longitudinal and time-to-event data: J. BARRETT AND L. SU. Statistics in Medicine. 2017 Apr 30;36(9):1447–60.
Barrett JK, Sweeting MJ, Wood AM. Dynamic Risk Prediction for Cardiovascular Disease: An Illustration Using the ARIC Study. In: Handbook of Statistics [Internet]. Elsevier; 2017 [cited 2018 Jun 14]. p. 47–65. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0169716117300044
Barber RM, Fullman N, Sorensen RJD, Bollyky T, McKee M, Nolte E, et al. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015. The Lancet. 2017 Jul;390(10091):231–66.
Armbrecht G, Felsenberg D, Ganswindt M, Lunt M, Kaptoge SK, Abendroth K, et al. Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over. Rheumatology. 2017 Jul 1;56(7):1189–99.