Surendrahttp://CEU2017n P…[203 authors] … Danesh J,Wain LV,Butterworth AS, Howson JMM*, Munroe PB*. Trans-ancestry meta-analyses identify rare and common variant associated with blood pressure and hypertension. (*equal senior contribution and joint corresponding authors) Nat Genet. 2016 Oct;48(10):1151-61.
Di Angelantonio E …[60 authors] … Thompson SG, Danesh J*, Hu FB*. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. (*equal senior contribution; JD was the sole corresponding author) Lancet 2016 Aug 20;388(10046):776-86.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar 11;351(6278):1166–71.
Willeit P, Thompson SG, Agewall S, Bergström G, Bickel H, Catapano AL, et al. Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration. European Journal of Preventive Cardiology. 2016 Jan;23(2):194–205.
Willeit P, Kaptoge S, Welsh P, Butterworth AS, Chowdhury R, Spackman SA, et al. Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. The Lancet Diabetes & Endocrinology. 2016 Oct;4(10):840–9.
Wheeler GM, Sweeting MJ, Mander AP. AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. Katoh M, editor. PLOS ONE. 2016 Jul 12;11(7):e0159026.
Ulug P, Powell JT, Sweeting MJ, Bown MJ, Thompson SG, SWAN Collaborative Group. Meta-analysis of the current prevalence of screen-detected abdominal aortic aneurysm in women: Prevalence of screen-detected abdominal aortic aneurysm in women. British Journal of Surgery. 2016 Aug;103(9):1097–104.
UK10K Consortium, Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, et al. Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics. 2016 Nov;48(11):1303–12.
the INTERVAL Study, the UK10K Consortium, the Deciphering Developmental Disorders Study, Sifrim A, Hitz M-P, Wilsdon A, et al. Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. Nature Genetics. 2016 Sep;48(9):1060–5.
Taylor AE, Burgess S, Ware JJ, Gage SH, Richards JB, Davey Smith G, et al. Investigating causality in the association between 25(OH)D and schizophrenia. Scientific Reports [Internet]. 2016 Sep [cited 2018 Jun 22];6(1). Available from: http://www.nature.com/articles/srep26496
Swedish Schizophrenia Study, INTERVAL Study, DDD Study, UK10 K Consortium, Singh T, Kurki MI, et al. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nature Neuroscience. 2016 Apr;19(4):571–7.
Stunnenberg HG, Hirst M, Abrignani S, Adams D, de Almeida M, Altucci L, et al. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell. 2016 Nov;167(5):1145–9.
Stevens J, Erber-Oakkar E, Cui Z, Cai J, Virani SS, Di Angelantonio E, et al. Cardiovascular disease risk by assigned treatment using the 2013 and 1998 obesity guidelines: Evaluation of Obesity Guidelines. Obesity. 2016 Jul;24(7):1554–60.
Staley JR, Blackshaw J, Kamat MA, Ellis S, Surendran P, Sun BB, et al. PhenoScanner: a database of human genotype–phenotype associations. Bioinformatics. 2016 Oct 15;32(20):3207–9.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, et al. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine. 2016 Jun 1;8(341):341ra76-341ra76.
Podmore C, Meidtner K, Schulze MB, Scott RA, Ramond A, Butterworth AS, et al. Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study. Diabetes Care. 2016 Apr;39(4):572–81.
Peters SA, van der Schouw YT, Wood AM, Sweeting MJ, Moons KG, Weiderpass E, et al. Parity, breastfeeding and risk of coronary heart disease: A pan-European case–cohort study. European Journal of Preventive Cardiology. 2016 Nov;23(16):1755–65.
Paul DS, Teschendorff AE, Dang MAN, Lowe R, Hawa MI, Ecker S, et al. Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nature Communications. 2016 Nov 29;7:13555.
Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications. 2016 Jan 21;7:10023.
Patel R, Sweeting MJ, Powell JT, Greenhalgh RM. Endovascular versus open repair of abdominal aortic aneurysm in 15-years’ follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. The Lancet. 2016 Nov;388(10058):2366–74.
Ng ES-W, Diaz-Ordaz K, Grieve R, Nixon RM, Thompson SG, Carpenter JR. Multilevel models for cost-effectiveness analyses that use cluster randomised trial data: An approach to model choice. Statistical Methods in Medical Research. 2016 Oct;25(5):2036–52.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. New England Journal of Medicine. 2016 Mar 24;374(12):1134–44.
Murray J, Burgess S, Zuccolo L, Hickman M, Gray R, Lewis SJ. Moderate alcohol drinking in pregnancy increases risk for children’s persistent conduct problems: causal effects in a Mendelian randomisation study. Journal of Child Psychology and Psychiatry. 2016 May;57(5):575–84.
Muka T, Oliver-Williams C, Kunutsor S, Laven JSE, Fauser BCJM, Chowdhury R, et al. Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysis. JAMA Cardiology. 2016 Oct 1;1(7):767.
Muka T, Oliver-Williams C, Colpani V, Kunutsor S, Chowdhury S, Chowdhury R, et al. Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. DeAngelis MM, editor. PLOS ONE. 2016 Jun 17;11(6):e0157417.
Muka T, Koromani F, Portilla E, O’Connor A, Bramer WM, Troup J, et al. The role of epigenetic modifications in cardiovascular disease: A systematic review. International Journal of Cardiology. 2016 Jun;212:174–83.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, et al. Nipple- and areola-sparing mastectomy for the treatment of breast cancer. Cochrane Breast Cancer Group, editor. Cochrane Database of Systematic Reviews [Internet]. 2016 Nov 29 [cited 2018 Jun 21]; Available from: http://doi.wiley.com/10.1002/14651858.CD008932.pub3
Moore C, Bolton T, Walker M, Kaptoge S, Allen D, Daynes M, et al. Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals. Trials [Internet]. 2016 Dec [cited 2018 Jun 21];17(1). Available from: http://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1579-7
Lotta LA, Sharp SJ, Burgess S, Perry JRB, Stewart ID, Willems SM, et al. Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis. JAMA. 2016 Oct 4;316(13):1383.
Liao X, Norata GD, Polak JF, Stehouwer CD, Catapano A, Rundek T, et al. Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin? European Journal of Preventive Cardiology. 2016 Jul;23(11):1165–73.
Leermakers ET, Darweesh SK, Baena CP, Moreira EM, Melo van Lent D, Tielemans MJ, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis1,2. The American Journal of Clinical Nutrition. 2016 Feb 1;103(2):481–94.
Lee YS, Cho Y, Burgess S, Davey Smith G, Relton CL, Shin S-Y, et al. Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study. Human Molecular Genetics. 2016 Sep 1;25(17):3877–86.
Lacey RE, Zilanawala A, Webb E, Abell J, Bell S. Parental absence in early childhood and onset of smoking and alcohol consumption before adolescence. Archives of Disease in Childhood. 2016 Oct 10;archdischild-2016-310444.
Khera AV, Won H-H, Peloso GM, Lawson KS, Bartz TM, Deng X, et al. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. Journal of the American College of Cardiology. 2016 Jun;67(22):2578–89.
Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, et al. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. Journal of the American College of Cardiology. 2016 Feb;67(4):407–16.
Jackson D, Law M, Barrett JK, Turner R, Higgins JPT, Salanti G, et al. Extending DerSimonian and Laird’s methodology to perform network meta-analyses with random inconsistency effects. Statistics in Medicine. 2016 Mar 15;35(6):819–39.
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, et al. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications. 2016 Jan 28;7:10531.
Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey Smith G. Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. The American Journal of Clinical Nutrition. 2016 Apr 1;103(4):965–78.
Harrison EM, Gleadall NS, Ba X, Danesh J, Peacock SJ, Holmes M. Validation of self-administered nasal swabs and postage for the isolation of Staphylococcus aureus. Journal of Medical Microbiology. 2016 Dec 16;65(12):1434–7.
Gilchrist PT, Vrinceanu T, Béland S, Bacon SL, Ditto B. Disgust stimuli reduce heart rate but do not contribute to vasovagal symptoms. Journal of Behavior Therapy and Experimental Psychiatry. 2016 Jun;51:116–22.
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, et al. The genetic architecture of type 2 diabetes. Nature. 2016 Aug;536(7614):41–7.
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, et al. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. JAMA. 2016 Jun 21;315(23):2554.
Fisher SA, Allen D, Dorée C, Naylor J, Di Angelantonio E, Roberts DJ. Interventions to reduce vasovagal reactions in blood donors: a systematic review and meta-analysis: Interventions to reduce blood donor vasovagal reactions. Transfusion Medicine. 2016 Feb;26(1):15–33.
Exome Aggregation Consortium, Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 Aug;536(7616):285–91.
Evans JDW, Kaptoge S, Caleyachetty R, Di Angelantonio E, Lewis C, Parameshwar KJ, et al. Socioeconomic Deprivation and Survival After Heart Transplantation in England: An Analysis of the United Kingdom Transplant Registry. Circulation: Cardiovascular Quality and Outcomes. 2016 Nov;9(6):695–703.
Evans JDW, Girerd B, Montani D, Wang X-J, Galiè N, Austin ED, et al. BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis. The Lancet Respiratory Medicine. 2016 Feb;4(2):129–37.
Epstein D, García-Mochón L, Kaptoge S, Thompson SG. Modeling the costs and long-term health benefits of screening the general population for risks of cardiovascular disease: a review of methods used in the literature. The European Journal of Health Economics. 2016 Nov;17(8):1041–53.
Eppinga RN, Hagemeijer Y, Burgess S, Hinds DA, Stefansson K, Gudbjartsson DF, et al. Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. Nature Genetics. 2016 Dec;48(12):1557–63.
Emdin CA, Khera AV, Natarajan P, Klarin D, Won H-H, Peloso GM, et al. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. Journal of the American College of Cardiology. 2016 Dec;68(25):2761–72.
Duffy PE, Morrison R, Kabyemela E, Fried M, Spottiswoode N, Drakesmith H, et al. Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study. The American Journal of Tropical Medicine and Hygiene. 2016 Oct 5;95(4):817–26.
Di Angelantonio E, Bhupathiraju SN, Wormser D, Gao P, Kaptoge S, de Gonzalez AB, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. The Lancet. 2016 Aug;388(10046):776–86.
Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, et al. BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization. Diabetes. 2016 Oct;65(10):3002–7.
Collins R, Reith C, Emberson J, Armitage J, Baigent C, Blackwell L, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. The Lancet. 2016 Nov;388(10059):2532–61.
Cheng Y-C, Stanne TM, Giese A-K, Ho WK, Traylor M, Amouyel P, et al. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke. 2016 Feb;47(2):307–16.
CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, CKDGen Consortium, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nature Genetics. 2016 Oct;48(10):1162–70.
CHARGE-Heart Failure Consortium, EchoGen Consortium, METASTROKE Consortium, GIANT Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics. 2016 Oct;48(10):1151–61.
CHARGE-EchoGen Consortium, CHARGE-HF Consortium, Wellcome Trust Case Control Consortium, Ehret GB, Ferreira T, Chasman DI, et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics. 2016 Oct;48(10):1171–84.
Burgess S, Thompson SG, CRP CHD Genetics Collaboration. Methods for meta-analysis of individual participant data from Mendelian randomisation studies with binary outcomes. Statistical Methods in Medical Research. 2016 Feb;25(1):272–93.
Burgess S, Small DS. Predicting the Direction of Causal Effect Based on an Instrumental Variable Analysis: A Cautionary Tale. Journal of Causal Inference [Internet]. 2016 Jan 14 [cited 2018 Jun 21];0(0). Available from: https://www.degruyter.com/view/j/jci.ahead-of-print/jci-2015-0024/jci-2015-0024.xml
Burgess S, Harshfield E. Mendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the future. Current Opinion in Endocrinology & Diabetes and Obesity. 2016 Apr;23(2):124–30.
Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample Mendelian randomization: Burgess et al. Genetic Epidemiology. 2016 Nov;40(7):597–608.
Burgess S, Butterworth AS, Thompson JR. Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors. Journal of Clinical Epidemiology. 2016 Jan;69:208–16.
Britton A, O’Neill D, Bell S. Underestimating the Alcohol Content of a Glass of Wine: The Implications for Estimates of Mortality Risk. Alcohol and Alcoholism. 2016 Sep;51(5):609–14.
Britton A, Hardy R, Kuh D, Deanfield J, Charakida M, Bell S. Twenty-year trajectories of alcohol consumption during midlife and atherosclerotic thickening in early old age: findings from two British population cohort studies. BMC Medicine [Internet]. 2016 Dec [cited 2018 Jun 21];14(1). Available from: http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0656-9
Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genetic Epidemiology. 2016 May;40(4):304–14.
Batty GD, Stamatakis E, Bell S. Psychological Distress and Risk of Accidental Death in the General Population: Epidemiology. 2016 Nov;27(6):e38–40.
Batty GD, Bell S, Stamatakis E, Kivimäki M. Association of Systemic Inflammation With Risk of Completed Suicide in the General Population. JAMA Psychiatry. 2016 Sep 1;73(9):993.
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, et al. The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell. 2016 Nov;167(5):1415-1429.e19.