The projected increase in mortality attributable to coronary heart disease (CHD) is expected to be much greater in South Asia than in any other geographical area worldwide. Coronary mortality in South Asia is expected to more than double, in both men and women, over the next 20 years and become the leading cause of death in this region by 2020. Despite this excess disease burden, data are, however, sparse from studies investigating the determinants of CHD risk in South Asia generally, and in Pakistan in particular.
The Pakistan Risk of Myocardial Infarction Study (PROMIS), in this regard, is a collaborative study between the CEU, Centre for Non-Communicable Disease (CNCD), Pakistan and various academic and cardiology centres in Pakistan. This completed study has recruited over 15000 first-ever confirmed myocardial infarction (MI) cases and over 15000 healthy controls from six centres across Pakistan. Information collected on each participant include a detailed questionnaire (including extensive information on lifestyle and dietary habits tailored to local dietary patterns), blood samples (including serum, plasma and whole blood) and DNA extracted from white blood cells. Samples have been transported to the core laboratory at the Department of Public Health and Primary Care, University of Cambridge, for long-term storage and subsequent genetic and biochemical analyses.
PROMIS will contribute towards the South Asian efforts of the CEU to identify and understand the separate and combined influences of genetic and major lifestyle factors on the risk of MI, and to help elucidate intermediate causal pathways.
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