The key objectives of the BELIEVE prospective cohort study are to create a re-callable population and bio-resource involving a general South Asian population to:
(1) enable genetic discovery using diverse phenotypes (particularly those related to nutrition such as iron deficiency anaemia, fat-metabolism, infection, or environment-related aspects such as air and toxic metal pollution), causal evaluation and functional genomics;
(2) assess reliably the roles of established and unique locally-relevant risk factors on incident NCDs such as cardiovascular, cancer, diabetes and kidney diseases (ascertained by clinical records and standardised validation);
(3) help study discrepant risk factor patterns unique to this population (eg, unusually high tobacco usage, lowest average body mass index, highest physical inactivity rates) over time, in various age groups as a life-course approach; and their heritability; and
(4) create a well-characterised population base to set-up innovative and cost-effective behaviour modification and pharmaceutical interventions, suitable from a South-Asian context.