Building on the work of the global CARDIoGRAMplusC4D Consortium, the goal of the CARDIoGRAMplusC4D 1M+ Hearts project is to discover many additional genetic risk factors for susceptibility to coronary heart disease (CHD) through creation of the most powerful CHD genetics dataset for discovery work to date.

The project aims to combine results from various large-scale genotyping arrays (eg, GWAS array, CardioMetabochip array, Exome array, Biobank arrays etc) in well over one million participants. The initial focus is on studies that have already recorded genetic array information on CHD cases *and* controls. To enhance discovery power, we are using imputed data from the Haplotype Reference Consortium, a state-of-the-art imputation reference panel with associated online imputation servers to facilitate straightforward imputation. Later stages will consider involvement of relevant studies with available DNA samples that are as yet ungenotyped, as well as potentially other study designs (eg, CHD case-only studies).

If you have an eligible study that is not already contributing to this project, please register your interest at: https://docs.google.com/forms/d/e/1FAIpQLSeuTB83xh-gfevST2v_ZiJFiRQjECJcn-kG_k2gq2Bkk0WfNQ/viewform