Dr Antoniou is a Cancer Research UK Senior Cancer Research Fellow, with research interests in the development and application of statistical modelling techniques to the inherited susceptibility of cancer, in particular breast, ovarian and other common cancers.

Research focuses on two broad areas: the development and evaluation of risk prediction models for familial breast, ovarian, prostate and other cancers with a familial component; and the identification and characterisation of modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers through analysis of large scale genome-wide and candidate gene association studies.

Specific ongoing projects include: the development of the BOADICEA risk prediction algorithm which can be used for predicting the risk of developing breast or ovarian cancer and the likelihood of carrying BRCA1 and BRCA2 mutations; investigation of candidate polymorphisms as genetic modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers using data from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA); a genome-wide study of genetic modifiers of risk for BRCA1 mutation carries (BRCA1 GWAS).