Senior Trial Manager / Senior Research Associate
BSc (hons), PhD
Telephone: 01223 330332
With a background in scientific laboratory-based research, Kate gained her PhD in the Medical Faculty at the University of Bristol, where she worked for eight years. In 2001 she joined the Department of Public Health & Primary Care here at the University of Cambridge as a trial co-ordinator for the ProActive study, the Unit’s first randomised controlled trial. She then worked on the ADDITION studies, a series of studies investigating screening for and intensive treatment of diabetes in primary care. Kate was involved with two recent Unit studies funded by the NIHR School for Primary Care Research; the long-term follow-up of both the ProActive and ADDITION cohorts. She lead the co-ordination of the Get Moving Study and the SeRaHS study (Self-rated Health in Stroke), the PosMT after Stroke pilot, and worked with the MRC Epidemiology Unit on the FMR Study. Kate most recently lead the management of the PROPS Trial, part of the PolyPill Programme.
In addition to various trial-specific co-ordination responsibilities, Kate provides Unit-wide support and guidance on all trial management, ethical and regulatory issues. Kate is also the primary liaison point for the Unit with the Cambridge Clinical Trials Unit at Addenbrooke’s Hospital, with whom we worked closely on our two Unit drug studies, GLINT and PROPS, as well as for the local CRN and the RDS teams.
With an active interest in ethics and patient and public involvement (PPI) in research and clinical medicine, Kate is a lay member of a local NHS Research Ethics Committee.
Cooper AJ, Dearnley K, Williams KM, Sharp SJ, van Sluijs EM, Brage S, Sutton S, Griffin SJ (2015). Protocol for Get Moving: a randomised controlled trial to assess the effectiveness of three minimal contact interventions to promote fitness and physical activity in working adults. BMC Public Health. Mar 27; 15:296.
Griffin SJ, Simmons RK, Prevost AT, Williams KM, Hardeman W, Sutton S, Brage S, Ekelund U, Parker RA, Wareham NJ, Kinmonth AL and the ADDITION-Plus study team (2014). Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes: the ADDITION-Plus randomised controlled trial. Diabetologia 57(7):1308-1319.
Savory LA, Griffin SJ, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Simmons RK (2014). Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort. Diabet Med. 31, 148-155.
Simmons RK, Echouffo-Tcheugui JB, Sharp SJ, Sargeant LA, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ (2012). Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. The Lancet. 380, 1741-1748. 2013 BMJ Research Paper of the Year & RCGP Diabetes Research Paper of the Year
Charles M, Simmons RK, Williams KM, Roglic G, Sharp SJ, Kinmonth AL, Wareham NJ, Griffin SJ (2012). Cardiovascular risk reduction following diagnosis of diabetes by screening: 1-year results from the ADDITION-Cambridge trial cohort. Br J Gen Pract. 62 (599), 294-295.
Barakat A, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ, Simmons RK (2012). Changes in physical activity and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort. Diabet Med. 22, 1464-5491.
Hardeman W, Michie S, Kinmonth AL, Sutton S on behalf of the ProActive project team (2011). Do increases in physical activity encourage positive beliefs about further change in the ProActive cohort? Psychology and Health. 26 (7), 899-914.
Simon J Griffin, Rebecca K Simmons, Kate M Williams, A Toby Prevost, Wendy Hardeman, Julie Grant, Fiona Whittle, Sue Boase, Imogen Hobbis, Soren Brage, Kate Westgate, Tom Fanshawe, Stephen Sutton, Nicholas J Wareham, Ann Louise Kinmonth and for the ADDITION-Plus study team (2011). Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care. BMC Public Health. 11, 211.
Hardeman W, Kinmonth AL, Michie S, Sutton S on behalf of the ProActive project team (2011). Theory of Planned Behaviour cognitions do not predict self-reported or objective physical activity levels or change in the ProActive trial. British Journal of Health Psychology. 16, 135-150.
Sargeant LA, Simmons RK, Barling RS, Butler R, Williams KM, Prevost AT, Kinmonth AK, Wareham NJ and Griffin SJ. Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study (2010). Diabetic Medicine. 27, 995-1003.
Simmons RK, Van Sluijs E, Hardeman W, Sutton S, Griffin S on behalf of the ProActive project team (2010). Who will increase their physical activity? An examination of the predictors of change in objectively measured physical activity over 12 months in the ProActive cohort. BMC Public Health. 10, 226.
Jonathan Graffy, Julie Grant, Kate Williams, Simon Cohn, Sara Macbay, Simon Griffin, Ann Louise Kinmonth (2010). More than measurement: practice team experiences of screening for type 2 diabetes. Family Practice. 27 (4), 386-394.
Steele RM, Finucane FM, Simmons RK, Griffin SJ, Wareham NJ, Ekelund U, ProActive research team (2009). Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity. Diabet. Med. 26 (4), 362-369.
Hardeman W, Kinmonth AL, Michie S, Sutton S on behalf of the ProActive Project team (2009). Impact of a physical activity intervention program on cognitive predictors of behaviour among adults at risk of Type 2 diabetes (ProActive randomised controlled trial). The International Journal of Behavioral Nutrition and Physical Activity. 6, 16.
Justin B Echouffo-Tcheugui, Rebecca K Simmons, Kate M Williams, Roslyn S Barling, A Toby Prevost, Ann Louise Kinmonth, Nicholas J Wareham and Simon J Griffin (2009). The ADDITION-Cambridge trial protocol – a cluster randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients. BMC Public Health. 9, 136.
Echouffo-Tcheugui JB, Sargeant LA, Prevost AT, Williams KM, Barling RS, Butler R, Fanshawe T, Kinmonth AL, Wareham NJ, Griffin SJ (2008). How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes? Diabet. Med. 25, 1433–1439.
Ann Louise Kinmonth, Nicholas Wareham, Wendy Hardeman, Stephen Sutton, Toby Prevost, Tom Fanshawe, Kate Williams, Ulf Ekelund, David Spiegelhalter, Simon Griffin (2008). Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trial. The Lancet, 371, 41-48.
Simmons RK, Griffin SG, Steele R, Wareham NJ, Ekelund U, on behalf of the ProActive Research Team (2008). Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: Cohort analysis of the ProActive trial. Diabetologia, 51 (5), 787-794.
Hilarie Bateman, Sue Boase, Daksha Trivedi, Kate Williams, Bridget Gorham (2006). Acknowledging the contribution of nurses who support quality care through involvement in research studies. Quality in Primary Care, 14 (2), 71-76.
Kate Williams, Toby Prevost, Simon Griffin, Wendy Hardeman, William Hollingworth, David Spiegelhalter, Ulf Ekelund, Stephen Sutton, Nicholas Wareham, Ann Louise Kinmonth (2004). The ProActive Trial Protocol. Randomised controlled trial of efficacy of a family-focussed, home-based programme to increase physical activity among individuals at high risk of diabetes [ISRCTN 61323766]. BMC Public Health, 4: 48.
Kate is currently fortunate enough to spend most of her week on secondment as research programme manager at the charity Medical Detection Dogs.