Professor of Primary Care Research
MA, MSc, MBBS, MD, FFPH, FRCP(Ed)
Tel: 01223 330325
Jonathan Mant is Professor of Primary Care Research and Head of the Primary Care Unit at the University of Cambridge. He leads the Cardiovascular Research Group. He represents Cambridge in the National School for Primary Care Research. He trained as a public health physician in the Oxford Region, and from 1992-97 was clinical lecturer in public health medicine at the University of Oxford. From 1997-2008 he was based in the Department of Primary Care & General Practice at the University of Birmingham, moving to Cambridge in October 2008. He was associate director of the Stroke Research Network with responsibility for primary and community care from 2005-2015, and has chaired several NICE guideline development groups, including most recently for acute heart failure. He is an NIHR Senior Investigator, and chairs one of the NIHR sub-panels for Programme Grants for Applied Research.
Jonathan’s current research focuses on stroke prevention and treatment in primary care settings. He is currently chief investigator on one programme grant funded by NIHR on developing primary care stroke services, and is a co-investigator on two further NIHR programmes on optimising blood pressure control through self monitoring and through supporting medication adherence . He has a longstanding interest in screening for and treatment of atrial fibrillation.
Penaloza-Ramos MC, Jowett S, Barton P, Roalfe A,Fletcher K, Taylor CJ, Hobbs FR, McManus RJ, Mant J. Cost-effectiveness analysis of different systolic blood pressure targets for people with a history of stroke or transient ischaemic attack: Economic analysis of the PAST-BP study. Eur J Prev Cardiol 25 May 2016
Mavaddat N, van der Linde R, Parker R, Savva G, Kinmonth AL, Brayne C, Mant J. Relationship of Self-Rated Health to Stroke Incidence and Mortality in Older Individuals with and without a History of Stroke: A Longitudinal Study of the MRC Cognitive Function and Ageing (CFAS) Population. PLoS One 11(2):e0150178 2016
Mant J, McManus RJ, Roalfe A, Fletcher K, Taylor CJ, Martin U, Virdee S, Greenfield S, Hobbs FD. Different systolic blood pressure targets for people with history of stroke or transient ischaemic attack: PAST-BP (Prevention After Stroke-Blood Pressure) randomised controlled trial. BMJ 352:i708 2016
Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, Chalmers J, Mant J, Salam A, Rahimi K, Perkovic V, Rodgers A. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2015 Nov 7. pii: S0140-6736(15)00805-3.
Yerrakalva D, Mullis R, Mant J. The associations of “fatness,” “fitness,” and physical activity with all-cause mortality in older adults: A systematic review. Obesity (Silver Spring) 23(10):1944-1956 Oct 2015.
Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, et al. An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial. BMJ 350:h468 2015.
Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J, NICE Guideline Development Group for Acute Heart Failure. The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910 2015.
McManus RJ, Mant J, Haque MS, Bray EP, Bryan S, Greenfield SM, Jones MI, Jowett S, Little P, Penaloza C, Schwartz C, Shackleford H, Shovelton C, Williams B, Varghese J, Hobbs FDR. Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: The TASMIN-SR randomized clinical trial JAMA 2014; 312:799-808.
Mavaddat N, Roalfe A, Fletcher K, Lip GY, Hobbs FD, Fitzmaurice D, Mant J. Warfarin versus aspirin for prevention of cognitive decline in atrial fibrillation: randomized controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged Study). Stroke 2014; 45:1381-86
Rashid MA, Edwards D, Walter FM, Mant J. Medication-taking in coronary artery disease: A qualitative synthesis. Annals of Family Medicine May 2014;12:224-232
Chowdhury R, Khan H, Heydon E, Shroufi A, Fahimi S, Moore C, Stricker B, Mendis S, Hofman A, Mant J, and Oscar H. Franco. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical Consequences. European Heart Journal 2013; published on line August 1st doi:10.1093/eurheartj/eht295.
Scowcroft A, Lee S, Mant J. Thromboprophylaxis of elderly patients with AF in the UK: An analysis using the General Practice Research Database (GPRD) 2000–2009. Heart 2013; 99:127-132.
Sheppard JP, Singh S, Fletcher K, McManus RJ, Mant J. A cross-sectional study investigating the impact of age and sex on primary preventative treatment for cardiovascular disease in the West Midlands, UK. BMJ 2012; 344.
Lovibond K, Jowett S, Barton P, Caulfield M, Heneghan C, Hobbs R, Hodgkinson J, Mant J, Martin U, Williams B, Wonderling D, McManus RJ. Modelling the cost-effectiveness of different options for the diagnosis of high blood pressure in primary care Lancet 2011; 378:1219-1230