Director of the Centre for Cancer Genetic Epidemiology
Telephone: +44 01223 748629
Professor Douglas Easton is currently Director of the Centre for Cancer Genetic Epidemiology within the Department of Public Health and Primary Care. He studied Mathematical Statistics at the University of Cambridge before gaining a PhD in Genetic Epidemiology at the University of London in 1992. In 1995 he set up the Cancer Research UK Genetic Epidemiology Unit at Cambridge, where he was a CR-UK Principal Research Fellow from 2001-2011. He was awarded Professorship of Genetic Epidemiology in 2003.
His main research interest is in genetic susceptibility to common cancers. The aim of his research group is to identify and characterise genetic variants associated with cancer risk, with particular emphasis on the hormone related cancers. Much of their recent work has focused on the analysis of genome-wide association studies (GWAS) to characterise common susceptibility variants, and the characterisation of susceptibility loci through fine-mapping. The group has conducted GWAS in breast cancer, prostate, endometrial and testis cancer. Prof Easton’s group also co-ordinates three large international consortia: the Breast Cancer Association Consortium (BCAC), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL – a collaboration with Professor Ros Eeles) and (in collaboration with Dr Antoniou and Dr Georgia Chenevix-Trench) the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Current work includes evaluating the role of rarer variants in breast and prostate cancer, and susceptibility to cancer-related traits including breast density, steroid hormones and telomere length.
For a number of years Professor Easton has lectured for part of the MPhil in Epidemiology and currently mentors for PhD students. He also lectures for part of the Natural Sciences Tripos Biochemistry Course in the Department of Biochemistry.
Michailidou K, et al … (2013) Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 45 : 353-361.
Ghoussaini M, et al … (2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 44 : 312-318
Varghese JS, et al … (2012) Mammographic breast density and breast cancer: evidence of a shared genetic basis. Cancer Res 72 : 1478-84
Kote-Jarai Z, et al … (2011) Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet 43 : 785-791
Macinnis RJ, et al … (2011) A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact. Genet Epidemiol 35 : 549-556
Turnbull C, et al … (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 42:504-507.
Ahmed S, et al … (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41:585-590.
Al Olama AA, et al … (2009) Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 41 : 1058-1060
Eeles RA, et al … (2009) Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet 41 : 1116-1121
Eeles RA, et al … (2008) Identification of multiple novel prostate cancer susceptibility loci by a genome-wide association study. Nat Genet 40 : 316-321