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Jyoti graduated with Microbiology major and went on to MSC in Biotechnology with research project to generate nitrogen fixing cellulose digesting microbe by fusing the properties of Cellulomonas and Azotobacter. The fused bacteria over generations would show some remarkable genetic properties. This sparked an interest in genetics and the subsequent PhD addressed the effects of linker histones on chromatin structure function through distinct processes in rats. This of course followed the course in trying to understand the role of chromatin and gene inheritance in disease such as Mobius and Kippel feil and imprinted disease such as Prader willi and Angelman disorders. These studies gave me an insight into proteins and their processing, DNA modifications and DNA-protein-RNA interactions and cellular processes and role of RNA, DNA methylation and chromatin long range effects in Imprinting.
This was about the time when explosion in large scale experiments set off and large data became available and Jyoti started work at cataloging the interactions of initially proteins followed by other macro and small molecules into the newly formed INTACT database for molecular interactions at Eurorean Bioinformatic Institute. Here she have worked extensively with UniProt, PDB, GOA, PRIDE and REACTOME. Jyoti developed Bioinformatic, data anlysis and disambiguation along with semantic data mining skills here since the data was varied, from multiple sources and forms and needed to be analysed in depth for standardised presentation.
From here she joined SLaM BioResource to develop methods for standardised data entry and retrieve of Volunteer information as well as data associated with the volunteer samples. Jyoti carried over these skills to the NIHR BioResource where she is a senior data scientist.
NIHR BioResource uses volunteer recall based on Phenotypic, Genotypic and clinical data to aid translational research in the role of Data scientist she has the opportunity to analyse large data sets and develop pipelines for these analysis and aid the recall based on the study criteria.
- Chromatin structure function and its effect on Disease.
- Analysis of varied types of data and visualisation in relation to each other for better understanding of pathways within cellular systems.
- Statistical analysis
Further studies of the down-regulation by Factor I of the C3b feedback cycle using endotoxin as a soluble activator and red cells as a source of CR1 on sera of different complotype.
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
The MIntAct project–IntAct as a common curation platform for 11 molecular interaction databases.
Regulatory elements associated with paternally-expressed genes in the imprinted murine Angelman/Prader-Willi syndrome domain.
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium.
New gene functions in megakaryopoiesis and platelet formation.
PSICQUIC and PSISCORE: accessing and scoring molecular interactions.
Recurated protein interaction datasets.
MINT and IntAct contribute to the Second BioCreative challenge: serving the text-mining community with high quality molecular interaction data.
Condensation of DNA and chromatin by an SPKK-containing octapeptide repeat motif present in the C-terminus of histone H1.
Preferential condensation of SAR-DNA by histone H1 and its SPKK containing octapeptide repeat motif.