Key Publications
Key Publications by year: 2016, 2015, 2014, 2013, 2012, 2011-2004
Surendran P…[203 authors] … Danesh J,Wain LV,Butterworth AS, Howson JMM*, Munroe PB*. Trans-ancestry meta-analyses identify rare and common variant associated with blood pressure and hypertension. (*equal senior contribution and joint corresponding authors) Nat Genet. 2016 Oct;48(10):1151-61.
Di Angelantonio E …[60 authors] … Thompson SG, Danesh J*, Hu FB*. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. (*equal senior contribution; JD was the sole corresponding author) Lancet 2016 Aug 20;388(10046):776-86.
Emerging Risk Factors Collaboration, Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS …[85 authors] … Thompson SG, Danesh J. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015 Jul;314(1):52-60.
Interleukin 1 Genetics Consortium, Freitag DF, Butterworth AS, Willeit P, Howson JMM, Burgess S, Kaptoge S, Young R, Ho WK, Wood AM, Sweeting M, Spackman S, Staley JR, Ramond A, Harshfield E …[132 authors] … Di Angelantonio E, Chowdhury R, Nordestgaard BG, Saleheen D, Thompson SG, Danesh J. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2015 Apr;3(4):243-53.
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S …[69 authors] … Thompson SG, Danesh J. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA. 2014 Mar;311(12):1225-33.
RESCAN Collaborators, Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SG. Surveillance intervals for small abdominal aortic aneurysms: a meta-anaylsis. JAMA. 2013 Feb; 309 (8): 806-13.
The Emerging Risk Factors Collaboration, Di Angelantonio E …[143 authors] …Thompson SG, Walker M, Watson S, Wood AM, Wormser D, Zhao X, Danesh J. Lipid-related markers and cardiovascular disease prediction. JAMA 2012;307:2499-506.
The Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Pennells L, Wood AM …[273 authors] …Thompson SG, Danesh J. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012;367:1310-20.
IL6R Genetics Consortium and The Emerging Risk Factors Collaboration, Sarwar N, Butterworth AS, Freitag DF …[221 authors] … Samani NJ, Kaptoge S, Di Angelantonio E, Harari O, Danesh J. Interleukin-6 receptor pathways in coronary disease: a collaborative meta-analysis of 82 studies. Lancet 2012;379:1205-13.
Lorenz MW…[17 authors] …Thompson SG. Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual particpant data. Lancet 2012;379:2053-62.
2016
Evans JDW, Girerd B, Montani D, et al. BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis. Lancet Respir Med. 2016 Feb;4(2):129-37. ]
Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic architecture of type 2 diabetes. Nature. 2016 Aug 4;536(7614):41-7.
Lek M, Karczewski KJ, Minikel EV, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 2016 Aug 17;536(7616):285-91.
Willeit P, Kaptoge S, Welsh P, Butterworth AS, Chowdury R, Spackman S, Pennells L,Gao P, Burgess S, Freitag DF, Sweeting M, Wood AM, Cook NR, Judd S, Trompet S, Nambi V, Hecht Olsen M, Everett BM, Kee F, Ärnlöv J, Salomaa V, Levy D, Kauhanen J, Laukkanen JA, Kavousi M, Ninomiya T, Casas J-P, Daniels LB, Lind L, Kistorp CN, Rosenberg J, Mueller T, Rubattu S, Panagiotakos DB, Franco OH, de Lemos JA, Luchner A, St Marien K, Kizer JR, Kiechl S, Salonen JT, Wannamethee SG, Nordestgaard BG, Anderson J, Jørgensen T, Melander O, Ballantyne CM, DeFilippi C, Ridker PM, Cushman M, Rosamond WD, Thompson SG, Gudnason V, Sattar N, Danesh J, Di Angelantonio E Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. Lancet Diabetes Endocrinol. 2016 Oct;4(10):840-9.
Patel R, Sweeting MJ, Powell JT, Greenhalgh RM. Endovascular versus open repair of abdominal aortic aneurysm in 15-years follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. Lancet 2016 Oct [Epub ahead of print].
Surendran P, Drenos F, Young R, Howson JMM*, Munroe PB*. (*joint senior author) et al. Trans-ancestry meta-analyses identify rare and common variant associated with blood pressure and hypertension. Nat Genet. 2016 Oct;48(10):1151-61.
Di Angelantonio E, Bhupathiraju SN, Wormser D, Danesh J*, Hu FB*, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016 Aug 20;388(10046):776-86.
Zanoni P, Khetarpal SA, Larach DB, Danesh J, Kathiresan S, Radar DJ, et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar;351(6278):1116-71.
Eppinga RN, Hagemeijer, Burgess S, Hinds DA, Gudbjartsson DF, van Veldhuisen DJ, Munroe PJ, Verweij N, van der Harst P. Shared genetic predictors of resting heart rate and all-cause mortality. Nat Genet. 2016 [in press].
Chen L, Ge B, Casale FP, et al. A human variation panel of genetic influences on epigenomes and transcriptomes in three immune cell types. Cell. 2016 [in press]
2015
Nikpay M, Goel A, Won HH,CARDIoGRAMplusC4D Consortium, et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015 Oct;47(10):1121-30.
Emerging Risk Factors Collaboration, Di Angelantonio E, Kaptoge S, Wormser D, et al. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015 Jul;314(1):52-60.
Interleukin 1 Genetics Consortium, Freitag DF, Butterworth AS, Willeit P, et al. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2015 Apr;3(4):243-53.
Nelson CP, Hamby SE, Saleheen D, et al. Genetically determined height and coronary artery disease. N Engl J Med. 2015 Apr;372(17):1608-18.
Do R, Stitziel NO, Won HH, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb;518(7537):102-6.
Shungin D, Winkler TW, Croteau-Chonka DC,et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb;518(7538):187-96.
Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb;518(7538):197-206.
Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, InterAct C, Langenberg C, Wareham NJ, Forouhi NG. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2015 Jan;3(1):35-42.
Chambers JC, Loh M, Lehne B, et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study. Lancet Diabetes Endocrinol. 2015 Jan;3(7):526-34.
Thompson SG, Willeit P. UK Biobank comes of age. Lancet. 2015 Aug;386(9993):509-10.
2014
Myocardial Infarction Genetics Consortium I, Stitziel NO, Won HH, Morrison AC, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov;371(22):2072-82.
Wormser D, Wood AM, Di Angelantonio E, Thompson SG, Danesh J, Emerging Risk Factors Collaboration. Metabolic mediators of body-mass index and cardiovascular risk. Lancet. 2014 Jun;383(9934):2042-3.
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, et al. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA. 2014 Mar;311(12):1225-33.
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D- GENES) Consortium, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234–44.
Danaei G, Lu Y, Singh GM, et al. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: A comparative risk assessment. Lancet Diabetes Endocrinol. 2014 Jan;2(8):634-47.
Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta- analysis. BMJ. 2014 (Jul);349:g4227.
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014 (Apr);348:g1903.
Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A, Di Angelantonio E, Gudnason V, Rumley A, Lowe GD, Jørgensen T, Danesh J. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J. 2014 Mar;35(9):578-89.
IMPROVE Trial Investigators, Powell JT, Sweeting MJ, Thompson MM, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve R, Heatley F, Hinchliffe RJ, Thompson SG, Ulug P. Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ. 2014 Jan 13;348:f7661.
Ng M, Fleming T, Robinson M,et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014 Aug;384(9945):766-81.
2013
Global Lipids Genetics C, Willer CJ, Schmidt EM, Sengupta S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-83.
Do R, Willer CJ, Schmidt EM, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov;45(11):1345-52.
Burgess S, Thompson SG. Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol. 2013 Aug;42(4): 1134-44.
Thanassoulis G, Campbell CY, Owens DS; CHARGE Extracoronary Calcium Working Group, et al. Genetic associations with valvular calcification and aortic stenosis. N Eng J Med 2013 Feb; 368(6) 503-12.
RESCAN Collaborators, Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SG. Surveillance intervals for small abdominal aortic aneurysms: a meta-anaylsis. JAMA. 2013 Feb; 309 (8): 806-13.
CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan;45(1):25-33.
Angelantonio E, Ford I, Sattar N. N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS. Eur Heart J 2013;(34) 443-50.
Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Budoff M, Fischer MJ, Rosas SE, Kanthety R, Rahman M, Master SR, Qasim A, Li M, Mehta NN,Shen H, Mitchell BD, O’Connell JR, Shuldiner AR, Ho WK, Young R, Rasheed A, Danesh J, He J, Kusek JW, Ojo AO, Flack J, Go AS, Gadegbeku CA, Wright JT Jr, Saleheen D, Feldman HI, Rader DJ, Foulkes AS, Reilly MP; CRIC Study Principal Investigators. Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J Am Coll Cardiol. 2013 Aug 27;62(9):789-98.
Wormser D, White IR, Thompson SG, Wood AM. Within person variability in calculated riskfactors: comparing the aetiological association of adiposity ratios with risk of coronary heart disease. Int J Epidemiol.2013 Jun;42(3):849-59.
Oliver-Williams C, Heydon EE, Smith GC, Wood AM. Miscarriage and future maternal cardiovascular disease: a systematic review and meta-analysis. Heart. 2013 Nov;99(22):1636-44.
2012
The Emerging Risk Factors Collaboration: (writing committee: Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A, Butterworth AS, Sarwar N, Wormser D, Saleheen D, Ballantyne CM, Psaty BM, Sundström J, Ridker PM, Nagel D, Gillum RF, Ford I, Ducimetiere P, Kiechl S, Koenig W, Dullaart RPF, Assmann G, D’Agostino RB, Dagenais GR, Cooper JA, Kromhout D, Onat A, Tipping RW, Gómez-de-la-Cámara A, Rosengren A, Sutherland SE, Gallacher J, Fowkes FGR, Casiglia E, Hofman A, Salomaa V, Barrett-Connor E, Clarke R, Brunner E, Jukema JW, Simons LA, Sandhu M, Wareham NJ, Khaw KT, Kauhanen J, Salonen JT, Howard WJ, Nordestgaard BG Wood AM, Thompson SG, Boekholdt SM, Sattar N, Packard C, Gudnason V, Danesh J). Lipid-related markers and cardiovascualar disease prediction. JAMA 2012;307:2499-506.
The Emerging Risk Factors Collaboration: (writing committee: Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, Butterworth AS, Amouyel P, Assmann G, Bakker SJL, Barr ELM, Barrett-Connor E, Benjamin MEJ, Björkelund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D’Agostino RB, Dankner R, Davey-Smith G, Deeg D, Dekker JM, Engström G, Folsom AR, Fowkes FGR, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jørgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Stehouwer CDA, Strandberg TE, Tipping RW, Tosetto A, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GDO, Sattar N, Wareham NJ, Khaw K-T, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J). C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012;367:1310-20.
van der Harst P, Zhang W, Mateo Leach, et al. Seventy-five genetic loci influencing the human red blood cell. Nature 2012;492:369-75.
The Emerging Risk Factors Collaboration: (writing committee: Wormser D, Di Angelantonio E, Kaptoge S, Wood A, Gao P, Sun Q, Wallidus G, Selmer R, Verschuren WMM, Bueno-de-Mesquita HB, Engström G, Ridker PM, Njølstrad I, Hiroyasu I,Holme I, Giampaoli S, Tunstall-Pedoe H, Gaziano JM, Brunner E, Kee F, Tosetto A, Meisinger C, Brenner H, Ducimetiere P, Whincup PH, Tippping RW, Ford I, Cremer P, Hofman A, Wihelmsen L, Clarke R, de Boer IH, Jukema JW, Ibanẽz AM, Lawlor DA, D’Agostino RB, Rodriguez B, Casiglia E, Stehouwer CDA, Simons LA, Nietert PJ, Barrett-Connor E, Panagiotakos DB, Björkelund C, Strandberg TE, Wassertheil-Smoller S, Blazer DG, Meade TW, Welin L, Svärdsudd K, Woodward M, Nissinen A, Kromhout D, Jørgensen T, Tilvis RS, Guralnik JM, Rosengren A, Taylor JO, Kiechl S, Dagenais GR, Fowkes FGR, Wallace RB, Khaw K-T, Shaffer JA, Visser M, Kauhanen J, Salonen JT, Gallacher J, Ben-Shlomo Y, Kitamura A, Sundström J, Kiyohara Y, Daimon M, Gómez de la Cámara A, Cooper JA, Onat A, Devereux R, Mukamal KJ, Dankner R, Knuiman MW, Crespo CJ, Gansevoort RT, Goldbourt U, Nordestgaard BG, Shaw JE, Mussolino M, Nakagawa H, Fletcher A, Kuller LH, Gillum RF, Gudnason V, Assmann G, Wald N, Jousilahti PR, Greenland P, Trevisan M, Ulmer H, Butterworth AS, Folsom AR, Davey-Smith G, Hu FB, Danesh J). Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. Int J Epidemiol 2012;41:1419-33.
Voight BF, Peloso GM, Orho-Melander M,et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012;380:572-80.
IL6R Genetics Consortium and The Emerging Risk Factors Collaboration: (writing committee: Sarwar N, Butterworth AS, Freitag DF, et al). Interleukin-6 receptor pathways in coronary disease: a collaborative meta-analysis of 82 studies. Lancet 2012;379:1205-13.
Burgess S, Butterworth A, Malarstig A, Thompson SG. Use of Mendelian randomisation to assess potential benefit of clinical intervention. BMJ 2012;345:e7325.
Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen TP, Sander D, Plichart M, Catapano AL, Robertson CM, Kiechl S, Rundek T, Desvarieux M, Lind L, Schmid C, DasMahapatra P, Gao L, Ziegelbauer K, Bots ML, Thompson SG; PROG-IMT Study Group. Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual particpant data. Lancet 2012;379:2053-62.
2011 – 2004
Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med, 2011
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet, 2011
C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20 536 patients in the Heart Protection Study Lancet, 2011
Wormser D…[195 co-authors]…Danesh J. Separate and combined associations of body- mass index and abdominal adiposity with cardiovascular disease. Lancet 2011;377:1085-95.
Sarwar N…[251 co-authors]…Danesh J. Triglyceride-mediated pathways and coronary disease. Lancet 2010;375:1634-9.
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet, 2010
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet, 2010
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet, 2010
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA, 2009
Major lipids, apolipoproteins, and risk of vascular disease. JAMA, 2009
Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA, 2008
Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA, 2007
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA, 2005
Antibiotics in the prevention of heart attacks. Lancet, 2005
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med, 2004
Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet, 2004